Cerebrospinal Fluid Concentration of Neuron-specific Enolase in Diagnosis of Creutzfeldt-Jakob Disease

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1995 Jun 24

PMID 7783539

Citations 27

Authors

I Zerr

M Bodemer

S Racker

S Grosche

S Poser

H A Kretzschmar

T Weber

Affiliations

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Abstract

Neuron-specific enolase (NSE) is among the biochemical markers in cerebrospinal fluid reported to be useful in the differential diagnosis of Creutzfeldt-Jakob disease from other dementing illnesses. In a group of 58 patients with definite and probable Creutzfeldt-Jakob disease, NSE concentrations (median 94.0, interquartile range 256 ng/mL) were significantly higher (p < 0.001) than in 26 control patients (9.5, 15.5 ng/mL). At a cut-off of 35 ng/mL an optimum sensitivity of 80% with a specificity of 92% for the diagnosis of Creutzfeldt-Jakob disease by NSE in cerebrospinal fluid was obtained.

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