The SWI-SNF Complex: a Chromatin Remodeling Machine?

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1995 Apr 1

PMID 7770913

Citations 157

Authors

C L Peterson

J W Tamkun

Affiliations

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Abstract

The SWI-SNF complex plays a key role in the regulation of eukaryotic gene expression. Genetic studies in the yeast Saccharomyces cerevisiae suggest that one role for the complex is to antagonize chromatin-mediated repression of transcription. Recent biochemical studies indicate that S. cerevisiae and putative human SWI-SNF complexes use the energy of ATP hydrolysis to disrupt nucleosome structure.

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