Polymorphic Acetylation of Nitrazepam

Overview

Journal J Med Genet

Specialty Genetics

Date 1976 Feb 1

PMID 775091

Citations 16

Authors

A K Karim

D A Evans

Affiliations

Soon will be listed here.

Abstract

Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).

Citing Articles

Determination of the acetylator phenotype and pharmacokinetics of some sulphonamides in man.

Vree T, OREILLY W, Hekster Y, Damsma J, van der Kleijn E Clin Pharmacokinet. 1980; 5(3):274-94.

PMID: 7389236 DOI: 10.2165/00003088-198005030-00006.

Human acetylator polymorphism: estimate of allele frequency in Libya and details of global distribution.

Karim A, Elfellah M, Evans D J Med Genet. 1981; 18(5):325-30.

PMID: 7328611 PMC: 1048751. DOI: 10.1136/jmg.18.5.325.

Interaction of phenelzine and nitrazepam in a slow acetylator.

Harris A, McIntyre N Br J Clin Pharmacol. 1981; 12(2):254-5.

PMID: 7306441 PMC: 1401853. DOI: 10.1111/j.1365-2125.1981.tb01212.x.

Clinical pharmacokinetics of nitrazepam.

Kangas L, Breimer D Clin Pharmacokinet. 1981; 6(5):346-66.

PMID: 7037262 DOI: 10.2165/00003088-198106050-00002.

The association of the slow acetylator phenotype with bladder cancer.

Evans D, Eze L, Whibley E J Med Genet. 1983; 20(5):330-3.

PMID: 6644762 PMC: 1049143. DOI: 10.1136/jmg.20.5.330.

References

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Evans D, DAVISON K, PRATT R . THE INFLUENCE OF ACETYLATOR PHENOTYPE ON THE EFFECTS OF TREATING DEPRESSION WITH PHENELZINE. Clin Pharmacol Ther. 1965; 6:430-5. DOI: 10.1002/cpt196564430. View

Evans D, White T . HUMAN ACETYLATION POLYMORPHISM. J Lab Clin Med. 1964; 63:394-403. View

Schroder H, Evans D . The polymorphic acetylation of sulphapyridine in man. J Med Genet. 1972; 9(2):168-71. PMC: 1469041. DOI: 10.1136/jmg.9.2.168. View

Karlsson E, Molin L . Polymorphic acetylation of procaine amide in healthy subjects. Acta Med Scand. 1975; 197(4):299-302. DOI: 10.1111/j.0954-6820.1975.tb04921.x. View