Ras Signaling and NF1

Overview

Journal Curr Opin Genet Dev

Publisher Elsevier

Specialties Biology
Genetics

Date 1995 Feb 1

PMID 7749326

Citations 23

Authors

F McCormick

Affiliations

Soon will be listed here.

Abstract

The gene responsible for the hereditary disease neurofibromatosis type 1 (NF1) has been well characterized as a regulator of Ras protein activity. Many aspects of the disease seem to be caused by misregulation of Ras as a result of NF1 mutation. Other aspects, however, point at functions for the NF1 protein that have yet to be discovered.

Citing Articles

C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis.

Perrino M, Ahmari N, Hall A, Jackson M, Na Y, Pundavela J Life Sci Alliance. 2024; 7(5.

PMID: 38458648 PMC: 10923703. DOI: 10.26508/lsa.202302229.

Schwann cells modulate nociception in neurofibromatosis 1.

Raut N, Maile L, Oswalt L, Mitxelena I, Adlakha A, Sprague K JCI Insight. 2024; 9(2).

PMID: 38258905 PMC: 10906222. DOI: 10.1172/jci.insight.171275.

Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.

Na Y, Hall A, Yu Y, Hu L, Choi K, Burgard J Oncogene. 2023; 42(13):1038-1047.

PMID: 36759572 PMC: 10194627. DOI: 10.1038/s41388-023-02620-x.

Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling.

Anastasaki C, Chatterjee J, Cobb O, Sanapala S, Scheaffer S, Costa A Acta Neuropathol Commun. 2022; 10(1):120.

PMID: 35986378 PMC: 9392324. DOI: 10.1186/s40478-022-01428-2.

Mutation of (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to Mutation.

Harigai R, Sato R, Hirose C, Takenouchi T, Kosaki K, Hirose T Cancers (Basel). 2022; 14(10).

PMID: 35625983 PMC: 9140047. DOI: 10.3390/cancers14102377.