Pattern of Neurobehavioral Deficits Associated with Interferon Alfa Therapy for Leukemia

Overview

Journal Neurology

Specialty Neurology

Date 1995 May 1

PMID 7746412

Citations 34

Authors

M A Pavol

C A Meyers

J L Rexer

A D Valentine

P J Mattis

M Talpaz

Affiliations

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Abstract

We evaluated the neuropsychological and personality profiles of 25 patients with chronic myelogenous leukemia treated with interferon alfa (IFN-alpha). This group of persons performed well below expectation on tests of cognitive speed, verbal memory, and executive functions. Personality changes included depression, increased somatic concern, and stress reactions. A control group of leukemia patients not treated with IFN-alpha had significantly better cognitive speed and mood. The pattern of cognitive and personality changes in patients receiving IFN-alpha is highly suggestive of frontal-subcortical brain dysfunction.

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