Clostridium Difficile and the Aetiology of Pseudomembranous Colitis

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1978 May 20

PMID 77366

Citations 179

Authors

H E Larson

A B Price

P Honour

S P Borriello

Affiliations

Soon will be listed here.

Abstract

Bacterial isolates from 5 patients with pseudomembranous colitis (P.M.C.) were screened for toxin production. Strains of Clostridium from 4 patients produced in vitro a toxin similar to that found in P.M.C. faecal suspension. These were identified as C. difficile. Use of the strains from 2 patients induced a fatal enterocolitis when inoculated orally into hamsters pretreated with vancomycin. The C. difficile that produced the toxin in vitro was then re-isolated from hamster caecal contents. These findings suggest that P.M.C. results from infection with C. difficile and that previous antibiotic therapy produces susceptibility to infection.

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