The Synthesis of S-adenosylmethionine by Mutants with Defects in S-adenosylmethionine Synthetase

Overview

Journal Mol Gen Genet

Specialties Genetics
Molecular Biology

Date 1976 Feb 27

PMID 772417

Citations 5

Authors

A C HOBSON

Affiliations

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Abstract

Some metK mutants of Salmonella typhimurium with constitutive methionine biosynthesis have no detectable S-adenosylmethionine (SAM) synthetase, the enzyme which converts methionine to SAM, the postulated corepressor of the methionine pathway. However, these mutants are not auxotrophic for SAM, an essential compound for many reactions.

Citing Articles

Novel Escherichia coli K-12 mutants impaired in S-adenosylmethionine synthesis.

Satishchandran C, Taylor J, Markham G J Bacteriol. 1990; 172(8):4489-96.

PMID: 2115868 PMC: 213279. DOI: 10.1128/jb.172.8.4489-4496.1990.

RNA methylation and control of eukaryotic RNA biosynthesis: processing and utilization of undermethylated tRNAs in CHO cells.

Amalric F, Bachellerie J, Caboche M Nucleic Acids Res. 1977; 4(12):4357-70.

PMID: 600798 PMC: 343246. DOI: 10.1093/nar/4.12.4357.

S-adenosyl methionine requiring mutants in Saccharomyces cerevisiae: evidences for the existence of two methionine adenosyl transferases.

Cherest H Mol Gen Genet. 1978; 163(2):153-67.

PMID: 355845 DOI: 10.1007/BF00267406.

Linkage map of Salmonella typhimurium, edition V.

Sanderson K, Hartman P Microbiol Rev. 1978; 42(2):471-519.

PMID: 353483 PMC: 281437. DOI: 10.1128/mr.42.2.471-519.1978.

Influence of methionine biosynthesis on serine transhydroxymethylase regulation in Salmonella typhimurium LT2.

Stauffer G, Brenchley J J Bacteriol. 1977; 129(2):740-9.

PMID: 320194 PMC: 235006. DOI: 10.1128/jb.129.2.740-749.1977.

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