Radiation Induced Isostaining: Fact or Fiction?

Overview

Journal Chromosoma

Specialty Molecular Biology

Date 1978 Apr 25

PMID 77215

Citations 2

Authors

P Gerner-Smidt

Affiliations

Soon will be listed here.

Abstract

Two different experiments were set up to induce differential staining in M-1(1) cells or to induce isostaining in M-2 cells after gamma-irradiation of human lymphocytes. Neither of these two unusual staining patterns previously described by Luchnik and Porjadkova (1977) were observed. Possible explanations for this disagreement are discussed.

Citing Articles

Sister chromatid differentiation and isolabeling of chromosomes.

Ved Brat S, Verma R, Dosik H Hum Genet. 1981; 56(3):305-8.

PMID: 6165669 DOI: 10.1007/BF00274684.

Chromosomal isolabelling caused by three rounds of synthesis in late replicating regions.

Wolff S, Bodycote J, Rodin B Chromosoma. 1978; 69(2):179-83.

PMID: 84735 DOI: 10.1007/BF00329916.

References

Kuebbing D, Werner R . A model for compartmentation of de novo and salvage thymidine nucleotide pools in mammalian cells. Proc Natl Acad Sci U S A. 1975; 72(9):3333-6. PMC: 432986. DOI: 10.1073/pnas.72.9.3333. View

Miller R, ARONSON M, Nichols W . Effects of treatment on differential staining of BrdU labeled metaphase chromosomes: three-way differentiation of M3 chromosomes. Chromosoma. 1976; 55(1):1-11. DOI: 10.1007/BF00288322. View

LA COUR L, PELC S . Effect of colchicine on the utilization of labelled thymidine during chromosomal reproduction. Nature. 1958; 182(4634):506-8. DOI: 10.1038/182506a0. View

LUCHNIK N, Porjadkova N . Isolabelling is a radiation-induced phenomenon. Chromosoma. 1977; 63(1):11-20. DOI: 10.1007/BF00292938. View