Evaluation of Portal Circulation Through the Superior Mesenteric Vein with an Enteric Capsule of [123I]iodoamphetamine

Overview

Journal J Gastroenterol

Specialty Gastroenterology

Date 1995 Feb 1

PMID 7719415

Authors

S Shiomi

T Kuroki

Y Miyazawa

T Ueda

T Takeda

S Nishiguchi

S Nakajima

K Kobayashi

H Ochi

Affiliations

Soon will be listed here.

Abstract

We report a method by which the contribution of the superior mesenteric vein to the portal blood flow can be evaluated noninvasively. An enteric-coated capsule containing [123I]iodoamphetamine is given by mouth 3h before the examination. The data obtained are treated by computer to calculate the portal shunt index (SI) through the superior mesenteric vein. The SI was higher for more severe liver disorders, Increasing in the order of chronic persistent hepatitis, chronic aggressive hepatitis, and cirrhosis. The SI was higher in cirrhotic patients than in chronic hepatitis patients or healthy volunteers (both, P < 0.0001). The SI was higher in cirrhotic patients with esophageal varices than in such patients without varices (P < 0.05). The SI was higher in cirrhotic patients with ascites than in such patients without ascites (P < 0.001). The SI was higher in cirrhotic patients with encephalopathy than in those without encephalopathy (P < 0.01). Correlation was significant between the SI and classical indicators of functional reserve. This method is clinically useful.

References

Urbain D, Jeghers O, Ham H . Per-rectal portal scintigraphy: comparison between technetium-99m, thallium-201, and iodine-123-HIPDM. J Nucl Med. 1988; 29(12):2020-1. View

Shiomi S, Kuroki T, Ueda T, Ikeoka N, Nishiguchi S, Nakajima S . Significance of blood flow in the inferior and superior mesenteric veins for the formation of oesophageal varices. J Gastroenterol Hepatol. 1991; 6(2):151-4. DOI: 10.1111/j.1440-1746.1991.tb01456.x. View

Hoshi H, Jinnouchi S, Watanabe K, Ueda T, Yamaguchi T . [Biodistribution of N-isopropyl-p-iodoamphetamine]. Nihon Igaku Hoshasen Gakkai Zasshi. 1987; 47(3):497-514. View

Okuda K, Suzuki K, Musha H, Arimuzu N . Percutaneous transhepatic catheterization of the portal vein for the study of portal hemodynamics and shunts. A preliminary report. Gastroenterology. 1977; 73(2):279-84. View

Steinberg M, Rasmussen J . Hepatography patterns following rectal administration of radioiodine as seen in chronic liver disease and other liver disorders. Scand J Gastroenterol. 1974; 9(1):73-9. View

Infante-Rivard C, Esnaola S, Villeneuve J . Clinical and statistical validity of conventional prognostic factors in predicting short-term survival among cirrhotics. Hepatology. 1987; 7(4):660-4. DOI: 10.1002/hep.1840070408. View

. Acute and chronic hepatitis revisited. Review by an international group. Lancet. 1977; 2(8044):914-9. View

HOLMAN B, Zimmerman R, Schapiro J, Kaplan M, Jones A, Hill T . Biodistribution and dosimetry of N-isopropyl-p-[123I]iodoamphetamine in the primate. J Nucl Med. 1983; 24(10):922-31. View

Clark R, Colley D, Jacobson E, Herman R, Tyler G, Stahl D . Superior mesenteric angiography and blood flow measurement following intra-arterial injection of prostaglandin E1. Radiology. 1980; 134(2):327-33. DOI: 10.1148/radiology.134.2.7352210. View

10.

Nakamura T, Nakamura S, Kaneko T . Flow of portal and hepatic blood in normal and cirrhotic liver. Nature. 1961; 190:812-3. DOI: 10.1038/190812b0. View

11.

DENCKER H, Gothlin J, HEDNER P, Lunderquist A, NORRYD C, Tylen U . Superior mesenteric angiography and blood flow following intra-arterial injection of prostaglandin F2alpha. Am J Roentgenol Radium Ther Nucl Med. 1975; 125(1):111-8. DOI: 10.2214/ajr.125.1.111. View

12.

Christensen E, Schlichting P, Andersen P, Fauerholdt L, Schou G, Pedersen B . Updating prognosis and therapeutic effect evaluation in cirrhosis with Cox's multiple regression model for time-dependent variables. Scand J Gastroenterol. 1986; 21(2):163-74. DOI: 10.3109/00365528609034642. View

13.

Tonami N, Nakajima K, Hisada K, Tanaka N, Kobayashi K . A noninvasive method for evaluating portal circulation by administration of Ti-201 per rectum. J Nucl Med. 1982; 23(11):965-72. View

14.

Yen C, POLLYCOVE M, Crass R, Lin T, Baldwin R, Lamb J . Portasystemic shunt fraction quantification with colonic iodine-123 iodoamphetamine. J Nucl Med. 1986; 27(8):1321-6. View

15.

Kashiwagi T, Azuma M, Ikawa T, Takehara T, Matsuda H, Yoshioka H . Portosystemic shunting in portal hypertension: evaluation with portal scintigraphy with transrectally administered I-123 IMP. Radiology. 1988; 169(1):137-40. DOI: 10.1148/radiology.169.1.3420249. View

16.

Pugh R, Murray-Lyon I, Dawson J, Pietroni M, Williams R . Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973; 60(8):646-9. DOI: 10.1002/bjs.1800600817. View

17.

Christensen E, Schlichting P, Fauerholdt L, Gluud C, Andersen P, Juhl E . Prognostic value of Child-Turcotte criteria in medically treated cirrhosis. Hepatology. 1984; 4(3):430-5. DOI: 10.1002/hep.1840040313. View

18.

ORREGO H, Israel Y, Blake J, Medline A . Assessment of prognostic factors in alcoholic liver disease: toward a global quantitative expression of severity. Hepatology. 1983; 3(6):896-905. DOI: 10.1002/hep.1840030602. View

19.

Shiomi S, Kuroki T, Ueda T, Nishiguchi S, Nakajima S, Kobayashi K . Prediction of esophageal varices in cirrhosis by per-rectal portal scintigraphy. Hepatogastroenterology. 1990; 37(6):544-5. View

20.

Tonami N, Nakajima K, Watanabe N, Seto M, Yokoyama K, Shuke N . Observation of portal circulation through superior mesenteric vein by enteric coated capsule of thallium-201. Eur J Nucl Med. 1988; 14(3):147-51. DOI: 10.1007/BF00293539. View