Antiphospholipid Antibodies and the Antiphospholipid Syndrome

Overview

Journal Springer Semin Immunopathol

Specialty Allergy & Immunology

Date 1994 Jan 1

PMID 7716706

Citations 7

Authors

E N Harris

S S Pierangeli

Affiliations

Soon will be listed here.

Abstract

The study of aPL antibodies and the APS has appealed to large numbers of investigators over the last decade. This accounts, in part, for the great degree of apparently contradictory data being published. What seems certain is that these antibodies are associated with thrombosis and recurrent pregnancy loss, and animal data suggest a direct role in pathogenesis. In vitro studies demonstrate that these antibodies have a variety of functional effects on the hemostatic system, giving further credence to an antibody role in thrombosis. Further studies will doubtless give better insight into the mechanisms of antibody action and this will provide a more rational basis for treatment.

Citing Articles

Plasmin immunization preferentially induces potentially prothrombotic IgG anticardiolipin antibodies in MRL/MpJ mice.

Ede K, Hwang K, Wu C, Wu M, Yang Y, Lin W Arthritis Rheum. 2009; 60(10):3108-17.

PMID: 19790056 PMC: 2775083. DOI: 10.1002/art.24818.

Some antiphospholipid antibodies recognize conformational epitopes shared by beta2-glycoprotein I and the homologous catalytic domains of several serine proteases.

Lin W, Chen P, Yang C, Cho E, Hahn B, Grossman J Arthritis Rheum. 2007; 56(5):1638-47.

PMID: 17469158 PMC: 1950582. DOI: 10.1002/art.22522.

Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome.

Lu C, Horizon A, Hwang K, FitzGerald J, Lin W, Hahn B Arthritis Rheum. 2005; 52(12):4018-27.

PMID: 16320350 PMC: 1950581. DOI: 10.1002/art.21485.

The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins).

Horkko S, Miller E, Branch D, Palinski W, Witztum J Proc Natl Acad Sci U S A. 1997; 94(19):10356-61.

PMID: 9294215 PMC: 23367. DOI: 10.1073/pnas.94.19.10356.

A monoclonal IgG anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in mice.

Olee T, Pierangeli S, Handley H, Le D, Wei X, Lai C Proc Natl Acad Sci U S A. 1996; 93(16):8606-11.

PMID: 8710918 PMC: 38720. DOI: 10.1073/pnas.93.16.8606.

References

Pengo V, Biasiolo A . Purification of anticardiolipin and lupus anticoagulant activities by using cardiolipin immobilized on agarose beads. Thromb Res. 1993; 72(5):423-30. DOI: 10.1016/0049-3848(93)90242-g. View

Marciniak E, Romond E . Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant. Blood. 1989; 74(7):2426-32. View

Love P, Santoro S . Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance. Ann Intern Med. 1990; 112(9):682-98. DOI: 10.7326/0003-4819-112-9-682. View

Boey M, Loizou S, Colaco C, Matkin J, Hughes G . Antithrombin III in systemic lupus erythematosus. Clin Exp Rheumatol. 1984; 2(1):53-6. View

Piette J, Wechsler B, Francis C, Godeau P . Systemic lupus erythematosus and the antiphospholipid syndrome: reflections about the relevance of ARA criteria. J Rheumatol. 1992; 19(12):1835-7. View

Francis Jr R, Neely S . Effect of the lupus anticoagulant on endothelial fibrinolytic activity in vitro. Thromb Haemost. 1989; 61(2):314-7. View

Levy R, Gharavi A, Sammaritano L, Habina L, Lockshin M . Fatty acid chain is a critical epitope for antiphospholipid antibody. J Clin Immunol. 1990; 10(3):141-5. DOI: 10.1007/BF00917913. View

Goldsmith G, Pierangeli S, Branch D, Gharavi A, Harris E . Inhibition of prothrombin activation by antiphospholipid antibodies and beta 2-glycoprotein 1. Br J Haematol. 1994; 87(3):548-54. DOI: 10.1111/j.1365-2141.1994.tb08311.x. View

Harris E . Special report. The Second International Anti-cardiolipin Standardization Workshop/the Kingston Anti-Phospholipid Antibody Study (KAPS) group. Am J Clin Pathol. 1990; 94(4):476-84. DOI: 10.1093/ajcp/94.4.476. View

10.

Lin Y, Wang C . Activation of human platelets by the rabbit anticardiolipin antibodies. Blood. 1992; 80(12):3135-43. View

11.

Silver R, Draper M, Scott J, Lyon J, Reading J, Branch D . Clinical consequences of antiphospholipid antibodies: an historic cohort study. Obstet Gynecol. 1994; 83(3):372-7. View

12.

Pierangeli S, Harris E . Antiphospholipid antibodies in an in vivo thrombosis model in mice. Lupus. 1994; 3(4):247-51. DOI: 10.1177/096120339400300408. View

13.

Harris E . Syndrome of the black swan. Br J Rheumatol. 1987; 26(5):324-6. DOI: 10.1093/rheumatology/26.5.324. View

14.

Khamashta M, Harris E, Gharavi A, Derue G, Gil A, Vazquez J . Immune mediated mechanism for thrombosis: antiphospholipid antibody binding to platelet membranes. Ann Rheum Dis. 1988; 47(10):849-54. PMC: 1003615. DOI: 10.1136/ard.47.10.849. View

15.

Intrator L, Oksenhendler E, Desforges L, Bierling P . Anticardiolipin antibodies in HIV infected patients with or without immune thrombocytopenic purpura. Br J Haematol. 1988; 68(2):269-70. DOI: 10.1111/j.1365-2141.1988.tb06206.x. View

16.

Jones J, James H, Tan M, Mansour M . Antiphospholipid antibodies require beta 2-glycoprotein I (apolipoprotein H) as cofactor. J Rheumatol. 1992; 19(9):1397-402. View

17.

McCrae K, DeMichele A, Pandhi P, Balsai M, Samuels P, Graham C . Detection of antitrophoblast antibodies in the sera of patients with anticardiolipin antibodies and fetal loss. Blood. 1993; 82(9):2730-41. View

18.

Derksen R, de Groot P, Kater L, Nieuwenhuis H . Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment. Ann Rheum Dis. 1993; 52(9):689-92. PMC: 1005149. DOI: 10.1136/ard.52.9.689. View

19.

Pierangeli S, Barker J, Stikovac D, Ackerman D, Anderson G, Barquinero J . Effect of human IgG antiphospholipid antibodies on an in vivo thrombosis model in mice. Thromb Haemost. 1994; 71(5):670-4. View

20.

Matsuura E, Igarashi Y, Yasuda T, Triplett D, Koike T . Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J Exp Med. 1994; 179(2):457-62. PMC: 2191370. DOI: 10.1084/jem.179.2.457. View