Peripheral Benzodiazepine Receptors and Glucose Metabolism in Human Gliomas

Overview

Journal J Neurooncol

Publisher Springer

Date 1994 Jan 1

PMID 7714547

Citations 5

Authors

C Ferrarese

C Pierpaoli

I Linfante

R H Bobo

B Guthrie

C Kufta

M O Duhaney

J Melisi

M J Fulham

Affiliations

Soon will be listed here.

Abstract

Peripheral benzodiazepine receptors (PBR) are increased in gliomas and augmented glucose metabolism is seen in malignant brain tumors. We investigated the relationship between PBR density (Bmax) and glucose utilization rate (GUR) in 17 patients with cerebral gliomas of different grades. PBR Bmax was assessed by [3H]PK-11195 in vitro binding in surgical specimens and GUR was measured by Positron Emission Tomography with [18F]2-Fluorodeoxyglucose before the surgery. In untreated tumors there was a positive correlation between PBR Bmax and GUR (2r = 0.84). This correlation was not observed in patients who had been treated with radiation and/or chemotherapy prior to surgery (r2 = 0.13). In addition, in untreated patients, the increase in PBR density and GUR appeared to be related to the degree of malignancy.

Citing Articles

Targeting Mitochondria for Cancer Treatment.

Zorova L, Abramicheva P, Andrianova N, Babenko V, Zorov S, Pevzner I Pharmaceutics. 2024; 16(4).

PMID: 38675106 PMC: 11054825. DOI: 10.3390/pharmaceutics16040444.

Imaging Metformin Efficacy as Add-On Therapy in Cells and Mouse Models of Human EGFR Glioblastoma.

Valtorta S, Lo Dico A, Raccagni I, Martelli C, Pieri V, Rainone P Front Oncol. 2021; 11:664149.

PMID: 34012924 PMC: 8126706. DOI: 10.3389/fonc.2021.664149.

Immunohistochemical expression of peripheral benzodiazepine receptors in human astrocytomas and its correlation with grade of malignancy, proliferation, apoptosis and survival.

Vlodavsky E, Soustiel J J Neurooncol. 2006; 81(1):1-7.

PMID: 16868661 DOI: 10.1007/s11060-006-9199-9.

The peripheral benzodiazepine receptors: a review.

Miccoli L, Oudard S, Dutrillaux B, Poupon M J Neurooncol. 2000; 46(1):45-56.

PMID: 10896204 DOI: 10.1023/a:1006456715525.

Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods.

Miyazawa N, Hamel E, Diksic M J Neurooncol. 1998; 38(1):19-26.

PMID: 9540054 DOI: 10.1023/a:1005933226966.

References

Papadopoulos V, Guarneri P, Kreuger K, Guidotti A, Costa E . Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Proc Natl Acad Sci U S A. 1992; 89(11):5113-7. PMC: 49239. DOI: 10.1073/pnas.89.11.5113. View

Benavides J, Cornu P, Dennis T, Dubois A, Hauw J, MacKenzie E . Imaging of human brain lesions with an omega 3 site radioligand. Ann Neurol. 1988; 24(6):708-12. DOI: 10.1002/ana.410240603. View

Daval J, Post R, Marangos P . Pyruvate dehydrogenase interactions with peripheral-type benzodiazepine receptors. J Neurochem. 1989; 52(1):110-6. DOI: 10.1111/j.1471-4159.1989.tb10904.x. View

Wang J, Morgan J, Spector S . Benzodiazepines that bind at peripheral sites inhibit cell proliferation. Proc Natl Acad Sci U S A. 1984; 81(3):753-6. PMC: 344914. DOI: 10.1073/pnas.81.3.753. View

Patronas N, DI CHIRO G, Brooks R, DelaPaz R, KORNBLITH P, Smith B . Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain. Radiology. 1982; 144(4):885-9. DOI: 10.1148/radiology.144.4.6981123. View

Ikezaki K, Black K, Toga A, Santori E, Becker D, Smith M . Imaging peripheral benzodiazepine receptors in brain tumors in rats: in vitro binding characteristics. J Cereb Blood Flow Metab. 1990; 10(4):580-7. DOI: 10.1038/jcbfm.1990.101. View

Katz Y, Ben-Baruch G, Kloog Y, Menczer J, Gavish M . Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries. Clin Sci (Lond). 1990; 78(2):155-8. DOI: 10.1042/cs0780155. View

Kadekaro M, Ito M, Gross P . Local cerebral glucose utilization is increased in acutely adrenalectomized rats. Neuroendocrinology. 1988; 47(4):329-34. DOI: 10.1159/000124933. View

Le Fur G, Perrier M, Vaucher N, Imbault F, Flamier A, Benavides J . Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies. Life Sci. 1983; 32(16):1839-47. DOI: 10.1016/0024-3205(83)90062-0. View

10.

Radford I . Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells. Int J Radiat Biol Relat Stud Phys Chem Med. 1986; 49(4):611-20. DOI: 10.1080/09553008514552861. View

11.

Kubota K, Ishiwata K, Kubota R, Yamada S, Tada M, Sato T . Tracer feasibility for monitoring tumor radiotherapy: a quadruple tracer study with fluorine-18-fluorodeoxyglucose or fluorine-18-fluorodeoxyuridine, L-[methyl-14C]methionine, [6-3H]thymidine, and gallium-67. J Nucl Med. 1991; 32(11):2118-23. View

12.

CAMMARANO P . Protein synthesis, glycolysis, and oxygen uptake in hepatoma cells irradiated in vitro. Radiat Res. 1963; 18:1-11. View

13.

Verma A, Nye J, Snyder S . Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor. Proc Natl Acad Sci U S A. 1987; 84(8):2256-60. PMC: 304628. DOI: 10.1073/pnas.84.8.2256. View

14.

Abe Y, Matsuzawa T, Fujiwara T, Fukuda H, Itoh M, Yamada K . Assessment of radiotherapeutic effects on experimental tumors using 18F-2-fluoro-2-deoxy-D-glucose. Eur J Nucl Med. 1986; 12(7):325-8. DOI: 10.1007/BF00263812. View

15.

DI CHIRO G, Brooks R, Patronas N, Bairamian D, KORNBLITH P, Smith B . Issues in the in vivo measurement of glucose metabolism of human central nervous system tumors. Ann Neurol. 1984; 15 Suppl:S138-46. DOI: 10.1002/ana.410150727. View

16.

McEwen B . Non-genomic and genomic effects of steroids on neural activity. Trends Pharmacol Sci. 1991; 12(4):141-7. DOI: 10.1016/0165-6147(91)90531-v. View

17.

Baril B, BARIL E, Laszlo J, WHEELER G . Inhibition of rat liver DNA polymerase by nitrosoureas and isocyanates. Cancer Res. 1975; 35(1):1-5. View

18.

Sokoloff L, Reivich M, Kennedy C, Des Rosiers M, PATLAK C, Pettigrew K . The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977; 28(5):897-916. DOI: 10.1111/j.1471-4159.1977.tb10649.x. View

19.

Valk P, Budinger T, Levin V, Silver P, Gutin P, Doyle W . PET of malignant cerebral tumors after interstitial brachytherapy. Demonstration of metabolic activity and correlation with clinical outcome. J Neurosurg. 1988; 69(6):830-8. DOI: 10.3171/jns.1988.69.6.0830. View

20.

Schneider M, OBOURKE F, REDETZKI H . X-irradiation and diphosphopyridine nucleotide (DPN) levels in ascites-tumour cells and liver tissue of mice. Int J Radiat Biol Relat Stud Phys Chem Med. 1962; 5:183-9. DOI: 10.1080/09553006214550691. View