The Protein Import Receptor of Mitochondria

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1995 Mar 1

PMID 7709435

Citations 46

Authors

T Lithgow

B S GLICK

G Schatz

Affiliations

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Abstract

Protein import into the mitochondria of Saccharomyces cerevisiae depends on two receptor subcomplexes composed of integral outer-membrane proteins. One subcomplex is the MAS37-MAS70 heterodimer, which preferentially recognizes the mature regions of precursor proteins associated with ATP-dependent cytosolic chaperones. The other subcomplex contains the acidic proteins MAS20 and MAS22, which recognize the positively charged targeting sequences of a wide variety of mitochondrial precursors. We propose that the two subcomplexes can act together as a single, multifunctional receptor that binds simultaneously to different regions of a precursor molecule.

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