Disproportionate Head Growth Retardation in Cystic Fibrosis

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1995 Feb 1

PMID 7702380

Citations 3

Authors

S Ghosal

C J Taylor

M Pickering

J McGaw

J K Wales

Affiliations

Soon will be listed here.

Abstract

Monthly increments of length, weight gain, and head circumference were recorded from birth to 4 years of age in 52 children with cystic fibrosis. At birth the children showed stunting. Standard deviation (SD) scores at birth for height, weight, and head circumference were -1.24, -0.72, and -1.82 respectively. Over the first four years, length and weight SD scores showed a consistent improvement. However, there was very limited improvement in head circumference, which stabilised 1 SD below the mean from 1.5 years to 4 years. Our data suggest that head growth lags behind gain in height and weight in children with cystic fibrosis despite good nutritional management in early infancy. The data may also support the expression of cystic fibrosis transmembrane conductance regulator in choroid plexus and ependyma.

Citing Articles

Growth deficits in cystic fibrosis mice begin in utero prior to IGF-1 reduction.

Darrah R, Bederman I, Vitko M, Valerio D, Drumm M, Hodges C PLoS One. 2017; 12(4):e0175467.

PMID: 28384265 PMC: 5383306. DOI: 10.1371/journal.pone.0175467.

Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth.

Rogan M, Reznikov L, Pezzulo A, Gansemer N, Samuel M, Prather R Proc Natl Acad Sci U S A. 2010; 107(47):20571-5.

PMID: 21059918 PMC: 2996661. DOI: 10.1073/pnas.1015281107.

Head growth in cystic fibrosis following early diagnosis by neonatal screening.

Ghosal S, Taylor C, Pickering M, McGaw J Arch Dis Child. 1996; 75(3):191-3.

PMID: 8976655 PMC: 1511694. DOI: 10.1136/adc.75.3.191.

References

Tanner J, Whitehouse R, Takaishi M . Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II. Arch Dis Child. 1966; 41(220):613-35. PMC: 2019692. DOI: 10.1136/adc.41.220.613. View

Sproul A, Huang N . GROWTH PATTERNS IN CHILDREN WITH CYSTIC FIBROSIS. J Pediatr. 1964; 65:664-76. DOI: 10.1016/s0022-3476(64)80151-7. View

Graham G . Effect of infantile malnutrition on growth. Fed Proc. 1967; 26(1):139-43. View

Pryor H, Thelander H . Abnormally small head size and intellect in children. J Pediatr. 1968; 73(4):593-8. DOI: 10.1016/s0022-3476(68)80275-6. View

Winick M, Rosso P . Head circumference and cellular growth of the brain in normal and marasmic children. J Pediatr. 1969; 74(5):774-8. DOI: 10.1016/s0022-3476(69)80140-x. View

Nelson K, Deutschberger J . Head size at one year as a predictor of four-year IQ. Dev Med Child Neurol. 1970; 12(4):487-95. DOI: 10.1111/j.1469-8749.1970.tb01944.x. View

Davies P, Davis J . Very low birth-weight and subsequent head growth. Lancet. 1970; 2(7685):1216-9. DOI: 10.1016/s0140-6736(70)92180-x. View

Engsner G, Habte D, Sjogren I, VAHLQUIST B . Brain growth in children with kwashiorkor. A study using head circumference measurement, transillumination and ultrasonic echo ventriculography. Acta Paediatr Scand. 1974; 63(5):687-94. DOI: 10.1111/j.1651-2227.1974.tb16991.x. View

LLOYD-STILL J, Hurwitz I, Wolff P, SHWACHMAN H . Intellectual development after severe malnutrition in infancy. Pediatrics. 1974; 54(3):306-11. View

10.

CROZIER D . Cystic fibrosis: a not-so-fatal disease. Pediatr Clin North Am. 1974; 21(4):935-50. DOI: 10.1016/s0031-3955(16)33069-3. View

11.

BERRY H, KELLOGG F, HUNT M, Ingberg R, Richter L, Gutjahr C . Dietary supplement and nutrition in children with cystic fibrosis. Am J Dis Child. 1975; 129(2):165-71. DOI: 10.1001/archpedi.1975.02120390009003. View

12.

Kraemer R, Rudeberg A, HADORN B, Rossi E . Relative underweight in cystic fibrosis and its prognostic value. Acta Paediatr Scand. 1978; 67(1):33-7. DOI: 10.1111/j.1651-2227.1978.tb16273.x. View

13.

Laron Z, Roitman A, KAULI R . Effect of human growth hormone therapy on head circumference in children with hypopituitarism. Clin Endocrinol (Oxf). 1979; 10(4):393-9. DOI: 10.1111/j.1365-2265.1979.tb02094.x. View

14.

Corey M, McLaughlin F, Williams M, Levison H . A comparison of survival, growth, and pulmonary function in patients with cystic fibrosis in Boston and Toronto. J Clin Epidemiol. 1988; 41(6):583-91. DOI: 10.1016/0895-4356(88)90063-7. View

15.

Chatfield S, Owen G, Ryley H, Williams J, Alfaham M, Goodchild M . Neonatal screening for cystic fibrosis in Wales and the West Midlands: clinical assessment after five years of screening. Arch Dis Child. 1991; 66(1 Spec No):29-33. PMC: 1590363. DOI: 10.1136/adc.66.1_spec_no.29. View

16.

Karlberg J, Kjellmer I, Kristiansson B . Linear growth in children with cystic fibrosis. I. Birth to 8 years of age. Acta Paediatr Scand. 1991; 80(5):508-14. DOI: 10.1111/j.1651-2227.1991.tb11894.x. View

17.

Thompson Jr R, Gustafson K, Meghdadpour S, Harrell E, Johndrow D, Spock A . The role of biomedical and psychosocial processes in the intellectual and academic functioning of children and adolescents with cystic fibrosis. J Clin Psychol. 1992; 48(1):3-10. DOI: 10.1002/1097-4679(199201)48:1<3::aid-jclp2270480102>3.0.co;2-h. View

18.

McGrath S, Basu A, Zeitlin P . Cystic fibrosis gene and protein expression during fetal lung development. Am J Respir Cell Mol Biol. 1993; 8(2):201-8. DOI: 10.1165/ajrcmb/8.2.201. View

19.

Tanner J, Whitehouse R, Takaishi M . Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. I. Arch Dis Child. 1966; 41(219):454-71. PMC: 2019592. DOI: 10.1136/adc.41.219.454. View