Influence of Polyunsaturated Fatty Acids on Survival of Skin Allografts and Tumor Incidence in Mice

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1976 Mar 1

PMID 768987

Citations 13

Authors

J Mertin

R Hunt

Affiliations

Soon will be listed here.

Abstract

Subcutaneous or oral administration of the polyunsaturated fatty acid linoleic acid prolongs survival of skin allografts in mice. Mice fed on a diet deficient in polyunsaturated fatty acids show a relative immunopotentiation, as indicated by accelerated skin allograft rejection and decreased incidence and rate of development of methylcholanthrene-induced tumors. These observations support the hypothesis that polyunsaturated fatty acids take part in immunoregulatory mechanisms.

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References

Lichtenstein L, Gillespie E, Bourne H, Henney C . The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity. Prostaglandins. 1972; 2(6):519-28. DOI: 10.1016/s0090-6980(72)80040-6. View

Ring J, Seifert J, Mertin J, Brendel W . Letter: Prolongation of skin allografts in rats by treatment with linoleic acid. Lancet. 1974; 2(7892):1331. DOI: 10.1016/s0140-6736(74)90203-7. View

Jose D, GOOD R . Immune resistance and malnutrition. Lancet. 1972; 1(7745):314. DOI: 10.1016/s0140-6736(72)90309-1. View

Mertin J, Hughes D, Shenton B, Dickinson J . In-vitro inhibition by unsaturated fatty acids of the PPD- and PHA-induced lymphocyte response. Klin Wochenschr. 1974; 52(5):248-50. DOI: 10.1007/BF01468599. View

Kigoshi S, Ito R . High levels of free fatty acids in lymphoid cells, with special reference to their cytotoxicity. Experientia. 1973; 29(11):1408-10. DOI: 10.1007/BF01922845. View