Role of Somatostatin in Regulation of Insular-acinar Axis

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1993 Aug 1

PMID 7688275

Citations 3

Authors

M K Muller

J von Schonfeld

M V Singer

Affiliations

Soon will be listed here.

Abstract

Cysteamine is known to deplete somatostatin from pancreatic D cells. In the isolated perfused rat pancreas we investigated its effects on somatostatin and glucagon release as well as exocrine pancreatic secretion in the presence of 1.8 mM glucose. Cysteamine, 10 mM, released somatostatin, but had no effect on CCK-stimulated amylase secretion. Arginine-stimulated glucagon release, however, was significantly inhibited by cysteamine. Concomitantly we still observed stimulation of somatostatin secretion, but also a potentiation of CCK-stimulated amylase secretion. Our results are consistent with a role of somatostatin in the regulation of exocrine pancreatic secretion via its effect on pancreatic A and B cells.

Citing Articles

Effects of somatostatin (SMS) on pancreatic microcirculation.

Plusczyk T, Rathgeb D, Westermann S, FEIFEL G Dig Dis Sci. 1997; 42(11):2254-63.

PMID: 9398803 DOI: 10.1023/a:1018862616845.

The islet-acinar axis of the pancreas.

von Schonfeld J, Goebell H, Muller M Int J Pancreatol. 1994; 16(2-3):131-40.

PMID: 7868939 DOI: 10.1007/BF02944323.

The islet-acinar axis of the pancreas: is there a role for glucagon or a glucagon-like peptide?.

von Schonfeld J, Muller M Experientia. 1994; 50(5):442-6.

PMID: 7515009 DOI: 10.1007/BF01920743.

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