Photodynamic Therapy of Oral Cancer: Photosensitisation with Systemic Aminolaevulinic Acid

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1993 Jul 17

PMID 7687318

Citations 55

Authors

W E Grant

C Hopper

A J MacRobert

P M Speight

S G Bown

Affiliations

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Abstract

Photodynamic therapy with intravenous photosensitising drugs has been shown to be effective in the ablation of superficial cancers, but long-lasting photosensitivity is a serious disadvantage. Similar photosensitivity is a feature of certain types of porphyria. We present the first report of tumour necrosis brought about by photodynamic activation of a temporary endogenous porphyrin accumulation, after an oral dose of the haem precursor, 5-aminolaevulinic acid. In 4 patients, quantitative fluorescence microscopy showed that accumulation of the photoactive intermediate protoporphyrin IX peaked after 4-6 h in 4 oral cavity squamous cell carcinomas, returning to background in 24 h. Irradiation with non-thermal red laser light caused tumour necrosis in 3 patients.

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