Galanin-like Immunoreactivity in Extrinsic and Intrinsic Nerves to the Gut of the Atlantic Cod, Gadus Morhua, and the Effect of Galanin on the Smooth Muscle of the Gut

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1993 Mar 1

PMID 7682478

Citations 9

Authors

P Karila

A C Jonsson

J Jensen

S Holmgren

Affiliations

Soon will be listed here.

Abstract

The presence of galanin-like immunoreactivity in nerves to the stomach of the Atlantic cod has been investigated by immunohistochemistry. The distribution of ganglion cells showing galanin-like immunoreactivity was compared with the total distribution in nerves and ganglia. Projection studies were made to determine the origin of the galanin neurons. The effect of galanin was studied in smooth muscle strip preparations of the gut wall and arteries. Galanin-like immunoreactive ganglion cells frequently occurred along the vagal branches to the stomach. Most of them projected cranially. Immunoreactive nerve fibers were present in all layers of the gut and around arterial branches on the surface of the stomach. Ligations of the vagus and splanchnic nerves produced accumulations of immunoreactive material on both sides of the ligature. Galanin produced weak contractile effects unaffected by tetrodotoxin on the gut wall and on gut arteries. It is concluded that a population of the ganglion cells along the vagus nerve in the Atlantic cod contains a galanin-like peptide. Some of these cells may be parts of autonomic parasympathetic pathways innervating the gut of the Atlantic cod, having direct excitatory effects on the smooth muscles of the gut wall and gut arteries.

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References

Gibbins I . Target-related patterns of co-existence of neuropeptide Y, vasoactive intestinal peptide, enkephalin and substance P in cranial parasympathetic neurons innervating the facial skin and exocrine glands of guinea-pigs. Neuroscience. 1990; 38(2):541-60. DOI: 10.1016/0306-4522(90)90049-a. View

Courtice G . Effect of neuropeptide-Y and galanin on autonomic control of heart rate in the toad, Bufo marinus. J Auton Nerv Syst. 1991; 33(3):231-8. DOI: 10.1016/0165-1838(91)90023-v. View

Bauer F, Zintel A, Kenny M, Calder D, Ghatei M, Bloom S . Inhibitory effect of galanin on postprandial gastrointestinal motility and gut hormone release in humans. Gastroenterology. 1989; 97(2):260-4. DOI: 10.1016/0016-5085(89)90059-0. View

Ju G, Hokfelt T, Brodin E, Fahrenkrug J, Fischer J, Frey P . Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells. Cell Tissue Res. 1987; 247(2):417-31. DOI: 10.1007/BF00218323. View

Kummer W . Galanin- and neuropeptide Y-like immunoreactivities coexist in paravertebral sympathetic neurones of the cat. Neurosci Lett. 1987; 78(2):127-31. DOI: 10.1016/0304-3940(87)90620-3. View

Ahren B, Bottcher G, Kowalyk S, Dunning B, Sundler F, Taborsky Jr G . Galanin is co-localized with noradrenaline and neuropeptide Y in dog pancreas and celiac ganglion. Cell Tissue Res. 1990; 261(1):49-58. DOI: 10.1007/BF00329437. View

Morris J, Gibbins I, Osborne P . Galanin-like immunoreactivity in sympathetic and parasympathetic neurons of the toad Bufo marinus. Neurosci Lett. 1989; 102(2-3):142-8. DOI: 10.1016/0304-3940(89)90069-4. View

Fox J, Brooks B, McDonald T, Barnett W, Kostolanska F, Yanaihara C . Actions of galanin fragments on rat, guinea-pig, and canine intestinal motility. Peptides. 1988; 9(5):1183-9. DOI: 10.1016/0196-9781(88)90105-2. View

Abrahamsson T . Axonal transport of adrenaline, noradrenaline and phenylethanolamine-N-methyl transferase (PNMT) in sympathetic neurons of the cod, Gadus morhua. Acta Physiol Scand. 1979; 105(3):316-25. DOI: 10.1111/j.1748-1716.1979.tb06347.x. View

10.

Yagci R, Alptekin N, Rossowski W, Brown A, Coy D, Ertan A . Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats. Scand J Gastroenterol. 1990; 25(8):853-8. DOI: 10.3109/00365529008999225. View

11.

Poulsen S, Holst J . Immunohistochemical detection of ganglia in the rat stomach serosa, containing neurons immunoreactive for gastrin-releasing peptide and vasoactive intestinal peptide. Histochemistry. 1987; 87(1):47-52. DOI: 10.1007/BF00518723. View

12.

Schepp W, Prinz C, Tatge C, Hakanson R, Schusdziarra V, Classen M . Galanin inhibits gastrin release from isolated rat gastric G-cells. Am J Physiol. 1990; 258(4 Pt 1):G596-602. DOI: 10.1152/ajpgi.1990.258.4.G596. View

13.

Ohhashi T, Jacobowitz D . Galanin potentiates electrical stimulation and exogenous norepinephrine-induced contractions in the rat vas deferens. Regul Pept. 1985; 12(2):163-71. DOI: 10.1016/0167-0115(85)90197-1. View

14.

Melander T, Hokfelt T, Rokaeus A, Fahrenkrug J, Tatemoto K, Mutt V . Distribution of galanin-like immunoreactivity in the gastro-intestinal tract of several mammalian species. Cell Tissue Res. 1985; 239(2):253-70. DOI: 10.1007/BF00218003. View

15.

Fox J, McDonald T, Kostolanska F, Tatemoto K . Galanin: an inhibitory neural peptide of the canine small intestine. Life Sci. 1986; 39(2):103-10. DOI: 10.1016/0024-3205(86)90443-1. View

16.

Dunning B, Ahren B, Veith R, Bottcher G, Sundler F, Taborsky Jr G . Galanin: a novel pancreatic neuropeptide. Am J Physiol. 1986; 251(1 Pt 1):E127-33. DOI: 10.1152/ajpendo.1986.251.1.E127. View

17.

Lindskog S, Ahren B . Galanin: effects on basal and stimulated insulin and glucagon secretion in the mouse. Acta Physiol Scand. 1987; 129(3):305-9. DOI: 10.1111/j.1748-1716.1987.tb08073.x. View

18.

Lindh B, Hokfelt T, Elfvin L, Terenius L, Fahrenkrug J, Elde R . Topography of NPY-, somatostatin-, and VIP-immunoreactive, neuronal subpopulations in the guinea pig celiac-superior mesenteric ganglion and their projection to the pylorus. J Neurosci. 1986; 6(8):2371-83. PMC: 6568766. View

19.

Gibbins I, Campbell G, Morris J, Nilsson S, Murphy R . Pathway-specific connections between peptide-containing preganglionic and postganglionic neurons in the vagus nerve of the toad (Bufo marinus). J Auton Nerv Syst. 1987; 20(1):43-55. DOI: 10.1016/0165-1838(87)90080-4. View

20.

Yau W, Dorsett J, Youther M . Evidence for galanin as an inhibitory neuropeptide on myenteric cholinergic neurons in the guinea pig small intestine. Neurosci Lett. 1986; 72(3):305-8. DOI: 10.1016/0304-3940(86)90531-8. View