Effects of Intermittent Hypoglycaemia in Pregnant Rats on the Functional Development of the Pancreatic B-cells of Their Offspring

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1976 Mar 1

PMID 767189

Citations 1

Authors

J C SODOYEZ

Affiliations

Soon will be listed here.

Abstract

Intermittent hypoglycaemia was induced by insulin injections into pregnant rats. At birth, the pups body weight and pancreatic insulin content were slightly but significantly decreased. In contrast, the B-cells of these newborn rats responded more markedly to a glucose challenge than the controls. The pancreases of the insulin injected rats were grearly depleted of insulin, possibly because of feedback inhibition of insulin synthesis by exogenous insulin. This inhibitory effect was restricted to the mother since the injected insulin did not cross the placental barrier. It is proposed that the nutrient supply to the fetus influenced body growth and pancreatic insulin accumulation whereas blood glucose variations, even intermittent hypoglycaemia, promoted precocious maturation of the B-cell glucoreceptor system.

Citing Articles

Effects of prolonged maternal fast on the pancreas of 18-21-day-old foetal rats. Ultrastructural and morphometric study of the beta cells.

Cell Tissue Res. 1984; 237(1):169-79.

PMID: 6383618 DOI: 10.1007/BF00229213.

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