Search for a Biochemical Basis of Diabetic Microangiopathy

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1976 Mar 1

PMID 767187

Citations 45

Authors

R G Spiro

Affiliations

Soon will be listed here.

Abstract

Diabetic microangiopathy, particularly as seen in the renal glomerulus, is characterized by morphological and biochemical alterations of the capillary basement membrane. Observations from a number of disciplines have indicated that the microvascular disease is not a separately inherited entity but a true consequence or "complication" of insulin deficiency. An evaluation of the biochemical events which could be responsible for the basement membrane lesions of diabetes indicates that the hyperglycemia or plasma somatotropin elevation of this disease alone, or in combination, may play an important role.

Citing Articles

NMR Metabolomics Show Evidence for Mitochondrial Oxidative Stress in a Mouse Model of Polycystic Ovary Syndrome.

Selen E, Bolandnazar Z, Tonelli M, Butz D, Haviland J, Porter W J Proteome Res. 2015; 14(8):3284-91.

PMID: 26076986 PMC: 6681913. DOI: 10.1021/acs.jproteome.5b00307.

Influence ofL-arginine on glucose mediated collagen cross link precursors in patients with diabetes mellitus.

Lubec G, Vierhapper H, Bailey A, Damjancic P, Fasching P, Sims T Amino Acids. 2013; 1(1):73-80.

PMID: 24194049 DOI: 10.1007/BF00808093.

Regulation of metabolic pathways in liver and kidney during experimental diabetes: Effects of antidiabetic compounds.

Baquer N, Gupta D, Raju J Indian J Clin Biochem. 2012; 13(2):63-80.

PMID: 23105185 PMC: 3453566. DOI: 10.1007/BF02867866.

Diffusing capacity for carbon monoxide in children with type 1 diabetes.

Villa M, Montesano M, Barreto M, Pagani J, Stegagno M, Multari G Diabetologia. 2004; 47(11):1931-5.

PMID: 15565372 DOI: 10.1007/s00125-004-1548-7.

To bridge science and patient care in diabetes.

Berger M Diabetologia. 1996; 39(7):749-57.

PMID: 8817098 DOI: 10.1007/s001250050507.

References

Spiro R . Studies on the renal glomerular basement membrane. Preparation and chemical composition. J Biol Chem. 1967; 242(8):1915-22. View

Dixon H . A reaction of glucose with peptides. Biochem J. 1972; 129(1):203-8. PMC: 1174057. DOI: 10.1042/bj1290203. View

Aagenaes O, Moe H . Light- and electron-microscopic study of skin capillaries of diabetics. Diabetes. 1961; 10:253-9. DOI: 10.2337/diab.10.4.253. View

Spiro R . Studies on the renal glomerular basement membrane. Nature of the carbohydrate units and their attachment to the peptide portion. J Biol Chem. 1967; 242(8):1923-32. View

Otto H, Themann H, Wagner H . [Qualitative and quantitative electron microscopic studies of skin capillaries of young diabetic patients]. Klin Wochenschr. 1967; 45(6):299-307. DOI: 10.1007/BF01747100. View

Walker F, PATRICK R . Effect of insulin on the hexosamine content of alloxan diabetic rabbit vitreous humor. Diabetes. 1968; 17(2):105-7. DOI: 10.2337/diab.17.2.105. View

Beisswenger P, Spiro R . Human glomerular basement membrane: chemical alteration in diabetes mellitus. Science. 1970; 168(3931):596-8. DOI: 10.1126/science.168.3931.596. View

Ditzel J, Standl E . The problem of tissue oxygenation in diabetes mellitus. I. Its relation to the early functional changes in the microcirculation of diabetic subjects. Acta Med Scand Suppl. 1975; 578:49-58. View

Ireland J, Patnaik B, Duncan L . Glomerular ultrastructure in secondary diabetics and normal subjects. Diabetes. 1967; 16(9):628-35. DOI: 10.2337/diab.16.9.628. View

10.

DOLGER H . Clinical evaluation of vascular damage in diabetes mellitus. J Am Med Assoc. 2010; 134(16):1289-91. DOI: 10.1001/jama.1947.02880330011004. View

11.

McMANUS J . The periodic acid routing applied to the kidney. Am J Pathol. 1948; 24(3):643-53. PMC: 1942787. View

12.

Kefalides N . Isolation of a collagen from basement membranes containing three identical - chains. Biochem Biophys Res Commun. 1971; 45(1):226-34. DOI: 10.1016/0006-291x(71)90073-8. View

13.

Mann T, PARSONS U . Studies on the metabolism of semen; role of hormones. Effect of castration, hypophysectomy and diabetes. Relation between blood glucose and seminal fructose. Biochem J. 1950; 46(4):440-50. PMC: 1275445. DOI: 10.1042/bj0460440. View

14.

Peterson D, Greene W, Reaven G . Effect of experimental diabetes mellitus on kidney ribosomal protein synthesis. Diabetes. 1971; 20(10):649-54. DOI: 10.2337/diab.20.10.649. View

15.

KEIDING N, Root H, Marble A . Importance of control of diabetes in prevention of vascular complications. J Am Med Assoc. 1952; 150(10):964-9. DOI: 10.1001/jama.1952.03680100006003. View

16.

BLOODWORTH Jr J, ENGERMAN R, POWERS K . Experimental diabetic microangiopathy. I. Basement membrane statistics in the dog. Diabetes. 1969; 18(7):455-8. DOI: 10.2337/diab.18.7.455. View

17.

Marble A . RELATION OF CONTROL OF DIABETES TO VASCULAR SEQUELAE. Med Clin North Am. 1965; 49:1137-45. DOI: 10.1016/s0025-7125(16)33301-6. View

18.

GABBAY K . The sorbitol pathway and the complications of diabetes. N Engl J Med. 1973; 288(16):831-6. DOI: 10.1056/NEJM197304192881609. View

19.

MAUER S, Steffes M, Sutherland D, Michael A, Brown D . Studies of the rate of regression of the glomerular lesions in diabetic rats treated with pancreatic islet transplantation. Diabetes. 1975; 24(3):280-5. DOI: 10.2337/diab.24.3.280. View

20.

Howard Jr C . Basement membrane thickness in muscle capillaries of normal and spontaneously diabetic Macaca nigra. Diabetes. 1975; 24(2):201-6. DOI: 10.2337/diab.24.2.201. View