[The Significance of Beta2-microglobulin and Carcinoembryonic Antigen in the Diagnosis of the Carcinoma of the Pancreas (author's Transl)]

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1978 Mar 15

PMID 76694

Citations 3

Authors

W Mantel

D Neumeier

Ch Hannig

H Kristin

M Otte

Affiliations

Soon will be listed here.

Abstract

The concentration of beta2-microglobulin (beta2m) and carcinoembryonic antigen (CEA) was measured radioimmunologically in the sera of 79 patients with malignant disorders and 15 patients with chronic pancreatitis. Elevated levels of beta2m and CEA were found in 11 out of 22 patients with carcinoma of the pancreas, which sets off this malignancy from chronic pancreatitis and other malignant tumors. Only 3 patients with carcinoma of the pancreas exhibited serum levels within the normal range for both parameters and none of the patients with chronic pancreatitis was shown to have elevated levels of beta2m. The simultaneous determination of beta2m and CEA suggests itself for the diagnosis of pancreatic malignancy especially in the case of a tentative diagnosis of a pancreatic tumor.

Citing Articles

Serum beta 2-microglobulin in chronic diseases of the pancreas.

Pezzilli R, Billi P, Fiocchi M, Beltrandi E, Cappelletti O, Sprovieri G Int J Pancreatol. 1995; 17(2):161-6.

PMID: 7622938 DOI: 10.1007/BF02788534.

Human pancreatic adenocarcinoma line Capan-1 in tissue culture and the nude mouse: morphologic, biologic, and biochemical characteristics.

Kyriazis A, Kyriazis A, Scarpelli D, Fogh J, Rao M, Lepera R Am J Pathol. 1982; 106(2):250-60.

PMID: 6278935 PMC: 1916189.

[Clinical value of the combined determination of the plasma concentrations of beta 2m and of CEA in the primary diagnosis and the control of radical surgery of adenocarcinoma of the gastrointestinal tract (author's transl)].

Auer I, Watzel C, Hiesche K Klin Wochenschr. 1980; 58(23):1313-7.

PMID: 6162055 DOI: 10.1007/BF01478140.

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