Detection of Mutagenic Activity of Metronidazole and Niridazole in Body Fluids of Humans and Mice

Overview

Journal Science

Specialty Science

Date 1975 Jun 13

PMID 766186

Citations 22

Authors

M S Legator

T H Connor

M Stoeckel

Affiliations

Soon will be listed here.

Abstract

After humans were treated at therapeutic doses with the trichomonacide metronidazole (Flagyl) and the antischistosomal agent niridazole mutagenic activity was demonstrable in their urines when tested with the histidine auxotroph of Salmonella typhimurium. Both compounds were active in the host-mediated assay in mice, and evidence of activity was found in the blood and urine of mice treated with niridazole but not with metronidazole.

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