Comparison of Vasoactive Intestinal Peptide (VIP) and Secretin in Gastric Secretion and Mucosal Blood Flow

Overview

Journal Pflugers Arch

Specialty Physiology

Date 1976 Jan 30

PMID 765958

Citations 5

Authors

S J Konturek

A Dembinski

P Thor

R Krol

Affiliations

Soon will be listed here.

Abstract

VIP and secretin were compared in regard to their effects on gastric acid and pepsin secretion induced by pentagastrin histamine or a peptone meal as well as on gastric mucosal blood flow and meal induced serum gastrin level in conscious dogs provided with gastric fistulas and denervated fundic pouches. Both VIP and secretin caused a dose-related stimulation of basal pepsin outputs and inhibition of pentagastrin-induced acid secretion. VIP, like secretin, inhibited pentagastrin and meal-induced gastric acid secretion but in contrast to secretin it caused inhibition of acid response to histamine. Inhibition of acid secretion by VIP or secretin was accompanied by secondary reduction in gastric mucosal blood flow in tests with pentagastrin or histamine and by depression of the serum gastrin level in tests with a peptone meal. This study indicates that in comparison with secretin, VIP has a wider spectrum of inhibition of stimulated gastric secretion and may be considered as one of the enterogastrones released in the small intestine.

Citing Articles

Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system.

Iwasaki M, Akiba Y, Kaunitz J F1000Res. 2019; 8.

PMID: 31559013 PMC: 6743256. DOI: 10.12688/f1000research.18039.1.

Influence of vasoactive intestinal polypeptide on net water flux and cyclic adenosine 3',5'-monophosphate formation in the rat jejunum.

Beubler E Naunyn Schmiedebergs Arch Pharmacol. 1980; 313(3):243-7.

PMID: 6253842 DOI: 10.1007/BF00505740.

VIP-, substance P- and met-enkephalin-immunoreactive innervation of the human gastroduodenal mucosa and Brunner's glands.

Ferri G, Botti P, Biliotti G, Rebecchi L, Bloom S, Tonelli L Gut. 1984; 25(9):948-52.

PMID: 6205942 PMC: 1432483. DOI: 10.1136/gut.25.9.948.

Calcitonin gene related peptide inhibits basal, pentagastrin, histamine, and bethanecol stimulated gastric acid secretion.

Lenz H, Mortrud M, Rivier J, Brown M Gut. 1985; 26(6):550-5.

PMID: 2861147 PMC: 1432758. DOI: 10.1136/gut.26.6.550.

Effect of 13-NLE-motilin on gastric secretion, serum gastrin level and mucosal blood flow in dogs.

Konturek S, Dembinski A, Krol R, Wunsch E J Physiol. 1977; 264(3):665-72.

PMID: 321755 PMC: 1307785. DOI: 10.1113/jphysiol.1977.sp011688.

References

Wormsley K, GROSSMAN M . INHIBITION OF GASTRIC ACID SECRETION BY SECRETIN AND BY ENDOGENOUS ACID IN THE DUODENUM. Gastroenterology. 1964; 47:72-81. View

Johnson L, GROSSMAN M . Secretin: the enterogastrone released by acid in the duodenum. Am J Physiol. 1968; 215(4):885-8. DOI: 10.1152/ajplegacy.1968.215.4.885. View

Anson M . THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN. J Gen Physiol. 2009; 22(1):79-89. PMC: 2213732. DOI: 10.1085/jgp.22.1.79. View

Jacobson E, Swan K, GROSSMAN M . Blood flow and secretion in the stomach. Gastroenterology. 1967; 52(2):414-20. View

Johnson L, GROSSMAN M . Characteristics of inhibition of gastric secretion by secretin. Am J Physiol. 1969; 217(5):1401-4. DOI: 10.1152/ajplegacy.1969.217.5.1401. View

Jacobson E, LINFORD R, GROSSMAN M . Gastric secretion in relation to mucosal blood flow studied by a clearance technic. J Clin Invest. 1966; 45(1):1-13. PMC: 292662. DOI: 10.1172/JCI105313. View

Johnson L . Effect of gastric mucosal acidification on the action of pepsigogues. Am J Physiol. 1973; 225(6):1411-5. DOI: 10.1152/ajplegacy.1973.225.6.1411. View

VAGNE M, STENING G, BROOKS F, GROSSMAN M . Synthetic secretin: comparison with natural secretin for potency and spectrum of physiological actions. Gastroenterology. 1968; 55(2):260-7. View

Barbezat G, GROSSMAN M . Intestinal secretion: stimulation by peptides. Science. 1971; 174(4007):422-4. DOI: 10.1126/science.174.4007.422. View

10.

Thompson J, Reeder D, Bunchman H, Becker H, BRANDT Jr E . Effect of secretin on circulating gastrin. Ann Surg. 1972; 176(3):384-93. PMC: 1355412. DOI: 10.1097/00000658-197209000-00014. View

11.

GREGORY R . Gastric secretory responses after portal venous ligation. J Physiol. 1958; 144(1):123-37. PMC: 1356775. DOI: 10.1113/jphysiol.1958.sp006090. View

12.

GROSSMAN M . Gastrin, cholecystokinin, and secretin act on one receptor. Lancet. 1970; 1(7656):1088-9. DOI: 10.1016/s0140-6736(70)92758-3. View

13.

Konturek S, TASLER J, Obtulowicz W, Rehfeld J . Effect of metiamide, a histamine H2-receptor antagonist, on mucosal blood flow and serum gastrin level. Gastroenterology. 1974; 66(5):982-6. View

14.

Brooks A, STENING G, GROSSMAN M . Effect of gastric vagal denervation on inhibition of acid secretion by secretin. Am J Dig Dis. 1971; 16(3):193-202. DOI: 10.1007/BF02235238. View

15.

GROSSMAN M . Candidate hormones of the gut. I. Introduction. Gastroenterology. 1974; 67(4):730-1. View

16.

Konturek S, Biernat J, OLEKSY J . Serum gastrin and gastric acid responses to meals at various pH levels in man. Gut. 1974; 15(7):526-30. PMC: 1412979. DOI: 10.1136/gut.15.7.526. View

17.

Johnson L, Harrison L . Comparison of exogenous secretin and duodenal acidification of pepsin secretion in dogs. Am J Physiol. 1971; 221(3):784-7. DOI: 10.1152/ajplegacy.1971.221.3.784. View

18.

Yalow R, Berson S . Radioimmunoassay of gastrin. Gastroenterology. 1970; 58(1):1-14. View

19.

Brown J, Dryburgh J . A gastric inhibitory polypeptide. II. The complete amino acid sequence. Can J Biochem. 1971; 49(8):867-72. DOI: 10.1139/o71-122. View