Effects of Cyclosporin on Serum Hyaluronan Levels in Collagen Arthritis

Overview

Journal Inflamm Res

Specialties Allergy & Immunology
Pathology

Date 1995 Feb 1

PMID 7655989

Authors

K Takagishi

M Itoman

Y Goso

S Kuwao

H Miyahara

N Kaibara

Affiliations

Soon will be listed here.

Abstract

Serum hyaluronan (HA) levels were measured in a rat model of collagen arthritis using a sandwich enzyme-linked immunosorbent assay. Values became elevated as the arthritis developed, correlating with its severity. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. HA in the blood may thus provide a good quantitative marker for joint disease in rat collagen arthritis with potential as a tool for evaluation of drug efficacy in this experimental model.

References

Goldberg R, Rubin A . Serum hyaluronate as a marker for disease severity in the Lactobacillus casei model of arthritis in the rat. J Rheumatol. 1989; 16(1):92-6. View

Horslev-Petersen K, Bentsen K, Engstrom-Laurent A, Junker P, Halberg P, Lorenzen I . Serum amino terminal type III procollagen peptide and serum hyaluronan in rheumatoid arthritis: relation to clinical and serological parameters of inflammation during 8 and 24 months' treatment with levamisole, penicillamine, or azathioprine. Ann Rheum Dis. 1988; 47(2):116-26. PMC: 1003463. DOI: 10.1136/ard.47.2.116. View

Engstrom-Laurent A, Hallgren R . Circulating hyaluronate in rheumatoid arthritis: relationship to inflammatory activity and the effect of corticosteroid therapy. Ann Rheum Dis. 1985; 44(2):83-8. PMC: 1001578. DOI: 10.1136/ard.44.2.83. View

Trentham D, Townes A, Kang A . Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med. 1977; 146(3):857-68. PMC: 2180804. DOI: 10.1084/jem.146.3.857. View

Sloboda A, Birnbaum J, Oronsky A, Kerwar S . Studies on type II collagen-induced polyarthritis in rats. Effect of antiinflammatory and antirheumatic agents. Arthritis Rheum. 1981; 24(4):616-24. DOI: 10.1002/art.1780240408. View

Morales T, Hascall V . Correlated metabolism of proteoglycans and hyaluronic acid in bovine cartilage organ cultures. J Biol Chem. 1988; 263(8):3632-8. View

Takagishi K, Yamamoto M, Miyahara H, Hotokebuchi T, Kaibara N . Comparative study of effects of cyclosporins A and G on collagen arthritis in mice. Agents Actions. 1992; 37(3-4):284-9. DOI: 10.1007/BF02028121. View

Poole A, Witter J, Roberts N, Piccolo F, Brandt R, Paquin J . Inflammation and cartilage metabolism in rheumatoid arthritis. Studies of the blood markers hyaluronic acid, orosomucoid, and keratan sulfate. Arthritis Rheum. 1990; 33(6):790-9. DOI: 10.1002/art.1780330605. View

Goldberg R, Toole B . Hyaluronate inhibition of cell proliferation. Arthritis Rheum. 1987; 30(7):769-78. DOI: 10.1002/art.1780300707. View

10.

Chichibu K, Matsuura T, Shichijo S, Yokoyama M . Assay of serum hyaluronic acid in clinical application. Clin Chim Acta. 1989; 181(3):317-23. DOI: 10.1016/0009-8981(89)90237-4. View

11.

Kaibara N, Hotokebuchi T, Takagishi K, Katsuki I, Morinaga M, Arita C . Pathogenetic difference between collagen arthritis and adjuvant arthritis. J Exp Med. 1984; 159(5):1388-96. PMC: 2187290. DOI: 10.1084/jem.159.5.1388. View

12.

Courtenay J, Dallman M, Dayan A, Martin A, Mosedale B . Immunisation against heterologous type II collagen induces arthritis in mice. Nature. 1980; 283(5748):666-8. DOI: 10.1038/283666a0. View

13.

Mason R . Recent advances in the biochemistry of hyaluronic acid in cartilage. Prog Clin Biol Res. 1981; 54:87-112. View

14.

Weinblatt M, Coblyn J, Fraser P, Anderson R, Spragg J, Trentham D . Cyclosporin A treatment of refractory rheumatoid arthritis. Arthritis Rheum. 1987; 30(1):11-7. DOI: 10.1002/art.1780300102. View

15.

Ng C, Handley C, Mason R, Robinson H . Synthesis of hyaluronate in cultured bovine articular cartilage. Biochem J. 1989; 263(3):761-7. PMC: 1133497. DOI: 10.1042/bj2630761. View

16.

Stuart J, Townes A, Kang A . Collagen autoimmune arthritis. Annu Rev Immunol. 1984; 2:199-218. DOI: 10.1146/annurev.iy.02.040184.001215. View

17.

Levesque H, Delpech B, Le Loet X, Deshayes P . Serum hyaluronate in rheumatoid arthritis: study by affino-immunoenzymatic assay. Br J Rheumatol. 1988; 27(6):445-9. DOI: 10.1093/rheumatology/27.6.445. View

18.

Trentham D . Collagen arthritis as a relevant model for rheumatoid arthritis. Arthritis Rheum. 1982; 25(8):911-6. DOI: 10.1002/art.1780250801. View

19.

Kaibara N, Hotokebuchi T, Takagishi K, Katsuki I . Paradoxical effects of cyclosporin A on collagen arthritis in rats. J Exp Med. 1983; 158(6):2007-15. PMC: 2187153. DOI: 10.1084/jem.158.6.2007. View

20.

WOOD F, Pearson C, Tanaka A . Capacity of mycobacterial wax D and its subfractions to induce adjuvant arthritis in rats. Int Arch Allergy Appl Immunol. 1969; 35(5):456-67. DOI: 10.1159/000230198. View