Regulation of Gonadotropin-releasing Hormone (GnRH) Gene Expression in Hypothalamic Neuronal Cells

Overview

Journal Cell Mol Neurobiol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Neurology

Date 1995 Feb 1

PMID 7648611

Citations 11

Authors

M E Wierman

J M Bruder

J K Kepa

Affiliations

Soon will be listed here.

Abstract

1. Gonadotropin-releasing hormone (GnRH) is the hypothalamic releasing factor that controls pituitary gonadotropin subunit gene expression and indirectly gametogenesis and steroidogenesis from the gonad, which results in reproductive competence. 2. GnRH is synthesized in only about 1000 neurons in the hypothalamus and released in an episodic fashion down the median eminence to regulate gonadotropin biosynthesis. 3. Although much is known about the secretory dynamics of GnRH release, little is known about the pretranslational control of GnRH biosynthesis due to lack of appropriate model systems. The recent availability of immortalized neuronal cell lines that produce GnRH allows investigators for the first time to begin to dissect the factors that directly regulate GnRH gene expression. 4. This article reviews the current state of knowledge concerning the mechanisms that direct tissue-specific and peptide hormone control of GnRH biosynthesis.

Citing Articles

Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility.

Pandolfi E, Tonsfeldt K, Hoffmann H, Mellon P Endocrinology. 2019; 160(9):2151-2164.

PMID: 31211355 PMC: 6821215. DOI: 10.1210/en.2019-00113.

Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats.

McMillin M, DeMorrow S, Glaser S, Venter J, Kyritsi K, Zhou T Am J Physiol Gastrointest Liver Physiol. 2017; 313(5):G410-G418.

PMID: 28751425 PMC: 5792219. DOI: 10.1152/ajpgi.00421.2016.

Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids.

Martinez-Rivera F, Perez-Laspiur J, Santiago-Gascot M, Aleman-Reyes A, Garcia-Santiago E, Rodriguez-Perez Y PLoS One. 2017; 12(7):e0180409.

PMID: 28719635 PMC: 5515402. DOI: 10.1371/journal.pone.0180409.

Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b.

Kyritsi K, Meng F, Zhou T, Wu N, Venter J, Francis H Am J Pathol. 2017; 187(7):1551-1565.

PMID: 28502477 PMC: 5500827. DOI: 10.1016/j.ajpath.2017.03.013.

Fibroblast Growth Factor 8 Expression in GT1-7 GnRH-Secreting Neurons Is Androgen-Independent, but Can Be Upregulated by the Inhibition of DNA Methyltransferases.

Linscott M, Chung W Front Cell Dev Biol. 2016; 4:34.

PMID: 27200347 PMC: 4853385. DOI: 10.3389/fcell.2016.00034.

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