» Articles » PMID: 7639752

Ligand-induced Polyubiquitination of Receptor Tyrosine Kinases

Overview
Publisher Elsevier
Specialty Biochemistry
Date 1995 Aug 4
PMID 7639752
Citations 12
Authors
Affiliations
Soon will be listed here.
Abstract

The platelet-derived growth factor beta-receptor undergoes polyubiquitination as a consequence of ligand binding. In the present study, we have examined the ligand-induced receptor ubiquitination also in the other receptor tyrosine kinase (structurally different) subfamilies by immunoblotting with anti-ubiquitin antiserum. In addition to the platelet-derived growth factor alpha- and beta-receptors, all the monomeric receptor tyrosine kinases examined, such as the receptors for epidermal growth factor (subfamily I), colony stimulating factor-1 (subfamily III), and fibroblast growth factor (subfamily IV), were found to be ubiquitinated after ligand stimulation. However, the insulin receptor (subfamily II), which is a tetrameric molecule, was not. These data suggest that the ligand-induced polyubiquitination of the receptor is a general phenomenon observed in most of the monomeric receptor tyrosine kinases.

Citing Articles

Knockout of c-Cbl/Cbl-b slows c-Met trafficking resulting in enhanced signaling in corneal epithelial cells.

Tarvestad-Laise K, Ceresa B J Biol Chem. 2023; 299(10):105233.

PMID: 37690689 PMC: 10622846. DOI: 10.1016/j.jbc.2023.105233.


IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.

Schmid F, Schou K, Vilhelm M, Holm M, Breslin L, Farinelli P J Cell Biol. 2017; 217(1):151-161.

PMID: 29237719 PMC: 5748969. DOI: 10.1083/jcb.201611050.


Proteomic identification of protein ubiquitination events.

Xu G, Jaffrey S Biotechnol Genet Eng Rev. 2014; 29:73-109.

PMID: 24568254 PMC: 3937853. DOI: 10.1080/02648725.2013.801232.


Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling.

Rengarajan C, Matzke A, Reiner L, Orian-Rousseau V, Scholpp S PLoS One. 2014; 9(1):e86373.

PMID: 24466061 PMC: 3896487. DOI: 10.1371/journal.pone.0086373.


The UPS in diabetes and obesity.

Wing S BMC Biochem. 2008; 9 Suppl 1:S6.

PMID: 19007436 PMC: 2582800. DOI: 10.1186/1471-2091-9-S1-S6.