Sequences Within the Parvovirus Minute Virus of Mice NS2-specific Exon Are Required for Inclusion of This Exon into Spliced Steady-state RNA

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1995 Sep 1

PMID 7637034

Citations 6

Authors

Q Zhao

S Mathur

L R Burger

D J Pintel

Affiliations

Soon will be listed here.

Abstract

When the minute virus of mice NS2-specific exon was modified by either substitution or deletion, most P4-generated pre-mRNA was spliced from the large-intron donor at nucleotide 514 to the small-intron acceptor at nucleotide 2377. Improvement to consensus of large-intron splice sites in such mutants did not suppress exon skipping or restore large-intron excision. Therefore, sequences within the NS2-specific exon are required for inclusion of this exon into spliced, steady-state minute virus of mice RNA.

Citing Articles

Binding of CCCTC-Binding Factor (CTCF) to the Minute Virus of Mice Genome Is Important for Proper Processing of Viral P4-Generated Pre-mRNAs.

Boftsi M, Majumder K, Burger L, Pintel D Viruses. 2020; 12(12).

PMID: 33266080 PMC: 7760686. DOI: 10.3390/v12121368.

Splicing of the large intron present in the nonstructural gene of minute virus of mice is governed by TIA-1/TIAR binding downstream of the nonconsensus donor.

Choi E, Pintel D J Virol. 2009; 83(12):6306-11.

PMID: 19339348 PMC: 2687395. DOI: 10.1128/JVI.00213-09.

A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent manner.

Gersappe A, Pintel D Mol Cell Biol. 1999; 19(3):1640-50.

PMID: 10022852 PMC: 83958. DOI: 10.1128/MCB.19.3.1640.

CA- and purine-rich elements form a novel bipartite exon enhancer which governs inclusion of the minute virus of mice NS2-specific exon in both singly and doubly spliced mRNAs.

Gersappe A, Pintel D Mol Cell Biol. 1998; 19(1):364-75.

PMID: 9858560 PMC: 83894. DOI: 10.1128/MCB.19.1.364.

Intron definition is required for excision of the minute virus of mice small intron and definition of the upstream exon.

HAUT D, Pintel D J Virol. 1998; 72(3):1834-43.

PMID: 9499034 PMC: 109473. DOI: 10.1128/JVI.72.3.1834-1843.1998.

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