Effects of Clozapine on Smoking in Chronic Schizophrenic Outpatients

Overview

Journal J Clin Psychiatry

Specialty Psychiatry

Date 1995 Aug 1

PMID 7635849

Citations 38

Authors

T P George

M J Sernyak

D M Ziedonis

S W Woods

Affiliations

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Abstract

Background: The effects of clozapine administration on smoking were examined in chronic schizophrenic outpatients.

Method: Twenty-nine of 30 schizophrenic outpatients enrolled in a university-affiliated Community Mental Health Center clozapine clinic were retrospectively surveyed by semistructured questionnaire regarding smoking before and after clozapine administration.

Results: Smokers comprised 62% (N = 18) of patients, and within this group, there was a significant decrease in reported daily cigarette use during clozapine treatment compared with level of use when patients had been treated with typical neuroleptics (1.67 +/- 1.13 vs. 1.26 +/- 0.72 packs/day, p = .025).

Conclusion: Clozapine may alter smoking behaviors in chronic schizophrenics.

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