Receptor Binding of Glutamate in the Striatum of Rats Differing in Learning Capacity

Overview

Journal Neurosci Behav Physiol

Publisher Springer

Date 1995 Mar 1

PMID 7630506

Authors

I V Karpova

A I Gorodinskii

N F Suvorov

S A Dambinova

Affiliations

Soon will be listed here.

Abstract

A comparative investigation has been carried out for the first time of the receptor binding of glutamate with synaptic membranes and coarse fractions of the postsynaptic enlargements isolated from the striatum of rats differing in their capacity to develop an alimentary instrumental reflex. It was demonstrated that the number of that glutamate binding sites on the postsynaptic enlargements isolated from the striatum of rats capable of rapidly developing an alimentary instrumental reflex was increased as compared with animals not subjected to training. This relationship is maintained two months after the termination of training.

References

Tonkiss J, Morris R, Rawlins J . Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat. Exp Brain Res. 1988; 73(1):181-8. DOI: 10.1007/BF00279671. View

Mamounas L, Thompson R, Lynch G, Baudry M . Classical conditioning of the rabbit eyelid response increases glutamate receptor binding in hippocampal synaptic membranes. Proc Natl Acad Sci U S A. 1984; 81(8):2548-52. PMC: 345100. DOI: 10.1073/pnas.81.8.2548. View

Wu K, WASTERLAIN C, Sachs L, Siekevitz P . Effect of septal kindling on glutamate binding and calcium/calmodulin-dependent phosphorylation in a postsynaptic density fraction isolated from rat cerebral cortex. Proc Natl Acad Sci U S A. 1990; 87(14):5298-302. PMC: 54310. DOI: 10.1073/pnas.87.14.5298. View

Errami M, Nieoullon A . Development of a micromethod to study the Na+-independent L-[3H]glutamic acid binding to rat striatal membranes. I. Biochemical and pharmacological characterization. Brain Res. 1986; 366(1-2):169-77. DOI: 10.1016/0006-8993(86)91292-8. View

Hauber W, Schmidt W . Effects of intrastriatal blockade of glutamatergic transmission on the acquisition of T-maze and radial maze tasks. J Neural Transm Gen Sect. 1989; 78(1):29-41. DOI: 10.1007/BF01247111. View

FOSTER A, Fagg G . Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain. Eur J Pharmacol. 1987; 133(3):291-300. DOI: 10.1016/0014-2999(87)90025-2. View

Zaitsev S, Kurochkin I, Sergeeva M, Varfolomeev S . [Stability of opiate receptors of wet and lyophilized preparations of rat brain membranes]. Biokhimiia. 1984; 49(7):1127-33. View

Karpova I . [The content of dopamine, its metabolites and GABA in the nigrostriatal system of rats with different learning abilities]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1992; 42(1):161-3. View

Scatton B, Lehmann J . N-methyl-C-aspartate-type receptors mediate striatal 3H-acetylcholine release evoked by excitatory amino acids. Nature. 1982; 297(5865):422-4. DOI: 10.1038/297422a0. View

10.

Cohen R, Blomberg F, Berzins K, Siekevitz P . The structure of postsynaptic densities isolated from dog cerebral cortex. I. Overall morphology and protein composition. J Cell Biol. 1977; 74(1):181-203. PMC: 2109867. DOI: 10.1083/jcb.74.1.181. View

11.

Kennedy M . Regulation of synaptic transmission in the central nervous system: long-term potentiation. Cell. 1989; 59(5):777-87. DOI: 10.1016/0092-8674(89)90601-6. View

12.

Lynch G, Baudry M . The biochemistry of memory: a new and specific hypothesis. Science. 1984; 224(4653):1057-63. DOI: 10.1126/science.6144182. View

13.

Calverley R, Jones D . Contributions of dendritic spines and perforated synapses to synaptic plasticity. Brain Res Brain Res Rev. 1990; 15(3):215-49. DOI: 10.1016/0165-0173(90)90002-6. View

14.

Luini A, Goldberg O, Teichberg V . Differential sensitivity of selected brain areas to excitatory amino acids. Neurosci Lett. 1983; 41(3):307-12. DOI: 10.1016/0304-3940(83)90468-8. View

15.

Jaspers R, de Vries T, Cools A . Effects of intrastriatal apomorphine on changes in switching behaviour induced by the glutamate agonist AMPA injected into the cat caudate nucleus. Behav Brain Res. 1990; 37(3):247-54. DOI: 10.1016/0166-4328(90)90136-3. View

16.

Dambinova S, Gorodinskii A . [Molecular organization of glutamate-sensitive chemoexcitatory membranes of nerve cells. Binding of L-[3H]glutamate to synaptic membranes of the rat cerebral cortex]. Biokhimiia. 1984; 49(1):67-74. View