Article: Jejunal lysozyme activity and the Paneth cell in coeliac disease

The jejunal mucosa of patients with coeliac disease contains significantly fewer Paneth cells (PCC) per crypt (p less than 0.001) and tissue lysozyme activity (JLA) P less than 0.001) when compared with a group of subjects with normal jejunal mucosa. Neither PCC nor JLA return to normal with complete clinical recovery and otherwise complete histological recovery on a gluten free diet. There is a significant linear correlation between JLA and PCC suggesting that the Paneth cell is the principal source of jejunal lysozyme.

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References

1.

Dahlqvist A . METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES. Anal Biochem. 1964; 7:18-25. DOI: 10.1016/0003-2697(64)90115-0. View

2.

KUDINOVA T . [Lysozyme as a local defense factor in the gastrointestinal tract of patients with chronic diseases of the digestive organs]. Antibiotiki. 1976; 21(5):441-4. View

3.

Mallas E, Terry J, Asquith P, COOKE W . Serum lysozyme in inflammatory bowel and coeliac disease. J Clin Pathol. 1976; 29(7):598-600. PMC: 476124. DOI: 10.1136/jcp.29.7.598. View

4.

Toner P . Cytology of intestinal epithelial cells. Int Rev Cytol. 1968; 24:233-343. DOI: 10.1016/s0074-7696(08)61401-1. View

5.

Erlandsen S, Parsons J, Taylor T . Ultrastructural immunocytochemical localization of lysozyme in the Paneth cells of man. J Histochem Cytochem. 1974; 22(6):401-13. DOI: 10.1177/22.6.401. View

6.

Creamer B . Paneth-cell function. Lancet. 1967; 1(7485):314-6. DOI: 10.1016/s0140-6736(67)91245-7. View

7.

Creamer B, Pink I . Paneth-cell deficiency. Lancet. 1967; 1(7485):304-6. DOI: 10.1016/s0140-6736(67)91239-1. View

8.

Osserman E, Klockars M, Halper J, FISCHEL R . Effects of lysozyme on normal and transformed mammalian cells. Nature. 1973; 243(5406):331-5. DOI: 10.1038/243331a0. View

9.

Cornell H, TOWNLEY R . Investigation of possible intestinal peptidase deficiency in coeliac disease. Clin Chim Acta. 1973; 43(1):113-25. DOI: 10.1016/0009-8981(73)90126-5. View

10.

Erlandsen S, Chase D . Paneth cell function: phagocytosis and intracellular digestion of intestinal microorganisms. I. Hexamita muris. J Ultrastruct Res. 1972; 41(3):296-318. DOI: 10.1016/s0022-5320(72)90071-8. View

11.

Peeters T, VANTRAPPEN G . The Paneth cell: a source of intestinal lysozyme. Gut. 1975; 16(7):553-8. PMC: 1410982. DOI: 10.1136/gut.16.7.553. View

12.

Osserman E, LAWLOR D . Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J Exp Med. 1966; 124(5):921-52. PMC: 2138258. DOI: 10.1084/jem.124.5.921. View

13.

Douglas A, Booth C . Digestion of gluten peptides by normal human jejunal mucosa and by mucosa from patients with adult coeliac disease. Clin Sci. 1970; 38(1):11-25. DOI: 10.1042/cs0380011. View

Jejunal Lysozyme Activity and the Paneth Cell in Coeliac Disease