Association of Mouse Fibrinogen-like Protein with Murine Hepatitis Virus-induced Prothrombinase Activity

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1995 Aug 1

PMID 7609073

Citations 26

Authors

R L Parr

L Fung

J Reneker

J L Leibowitz

G Levy

Affiliations

Soon will be listed here.

Abstract

Previously, we demonstrated induction of a unique macrophage prothrombinase during infection of BALB/cJ mice by mouse hepatitis virus strain 3 (MHV-3). By immunologic screening, a clone representing this prothrombinase was isolated from a cDNA library and sequenced. The sequence identified this clone as representing part of a gene, musfiblp, that encodes a fibrinogen-like protein. Six additional clones were isolated, and one clone, p11-3-1, encompassed the entire coding region of musfiblp. Murine macrophages did not constitutively express musfiblp but, when infected with MHV-3, synthesized musfiblp-specific mRNA. musfiblp mRNA induction was earlier and significantly greater in BALB/cJ than A/J macrophages. Prothrombinase activity was demonstrated when musfiblp was expressed from p11-3-1 in RAW 264.7 cells. These data suggest that musfiblp encodes the MHV-induced prothrombinase.

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