Apoptosis Induced by High- and Low-LET Radiations

Overview

Journal Radiat Environ Biophys

Specialties Biophysics
Environmental Health
Oncology
Radiology

Date 1995 Mar 1

PMID 7604163

Citations 4

Authors

J H Hendry

C S Potten

A Merritt

Affiliations

Soon will be listed here.

Abstract

Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals.

Citing Articles

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Relative biological effectiveness of fast neutrons for apoptosis in mouse hair follicles.

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