In Vivo Induction of Apoptosis by Influenza Virus

Overview

Journal J Gen Virol

Specialty Microbiology

Date 1995 Nov 1

PMID 7595397

Citations 60

Authors

I Mori

T Komatsu

K Takeuchi

K Nakakuki

M Sudo

Y Kimura

Affiliations

Soon will be listed here.

Abstract

Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragmentation of nuclei and chromatin condensation. Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. These results suggest that the influenza virus induces apoptosis in vivo.

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