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Role of Epidermal Growth Factor in Peptic Ulcer Healing

Overview
Journal Dig Dis Sci
Specialty Gastroenterology
Date 1995 Nov 1
PMID 7587841
Citations 2
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Abstract

In recent years, increasing interest has been focused on peptide growth factors, and impressive progress has been made in the understanding of their role in tumor development and progression. However, evidence is mounting that peptides such as epidermal growth factor and transforming growth factor-alpha may be of much more physiological than pathological importance. This brief article is intended to give a rapid overview of the available data supporting a role for epidermal growth factor and its human homologue urogastrone in peptic ulcer healing.

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References
1.
Scheving L, Yeh Y, Tsai T, Scheving L . Circadian phase-dependent stimulatory effects of epidermal growth factor on deoxyribonucleic acid synthesis in the tongue, esophagus, and stomach of the adult male mouse. Endocrinology. 1979; 105(6):1475-80. DOI: 10.1210/endo-105-6-1475. View

2.
Konturek J, Bielanski W, Konturek S, Bogdal J, OLEKSY J . Distribution and release of epidermal growth factor in man. Gut. 1989; 30(9):1194-200. PMC: 1434230. DOI: 10.1136/gut.30.9.1194. View

3.
Cohen S . Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J Biol Chem. 1962; 237:1555-62. View

4.
Goodlad R, Wilson T, Lenton W, Gregory H, McCullagh K, Wright N . Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats. Gut. 1987; 28(5):573-82. PMC: 1432884. DOI: 10.1136/gut.28.5.573. View

5.
Lee H, Hansson H, Norstrom E, Helander H . Immunoreactivities for epidermal growth factor (EGF) and for EGF receptors in rats with gastric ulcers. Cell Tissue Res. 1991; 265(2):211-8. DOI: 10.1007/BF00398069. View