Stimulation and Inhibition of Macrophages Prior to Immunization with a Hapten-carrier Conjugate

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1977 Aug 1

PMID 75840

Citations 2

Authors

P J Neveu

Affiliations

Soon will be listed here.

Abstract

Delayed hypersensitivity reactions and antibody-mediated reactions to the carrier and to the hapten have been studied in animals treated with BCG or/and trypan blue before immunization with a hapten-carrier complex. The results show that it is possible to induce, with BCG, at the beginning of the response, an antigenic competition between hapten and carrier moieties of the antigen molecule. Macrophages which modulate the response to the hapten-carrier complex by acting both on T cells involved in cellular immunity and those involved in antibody synthesis, appear to be the target of antigenic competition.

Citing Articles

Modulation of antibody synthesis by an anti-tumour alga.

Neveu P, Morin O, Miegeville M, le Mevel B, VERMEIL C Experientia. 1978; 34(12):1644-5.

PMID: 729746 DOI: 10.1007/BF02034728.

The effects of thiol moiety of levamisole on both cellular and humoral immunity during the early response to a hapten-carrier complex.

Neveu P Clin Exp Immunol. 1978; 32(3):419-22.

PMID: 210988 PMC: 1541331.

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