Analysis of the Gc Polymorphism in Human Populations by Isoelectrofocusing on Polyacrylamide Gels. Demonstration of Subtypes of the Gc Allele and of Additional Gc Variants

Overview

Journal Hum Genet

Specialty Genetics

Date 1978 Feb 23

PMID 75833

Citations 27

Authors

J Constans

M Viau

H CLEVE

G Jaeger

J C QUILICI

M J Palisson

Affiliations

Soon will be listed here.

Abstract

For the study of the group-specific component (Gc) system, serum samples were examined by polyacrylamide gel electrophoresis and by a newly developed immunofixation isoelectrofocusing procedure. Thereby, a greater extent of polymorphic variation was revealed than was known previously. The allele Gc1 could be subdivided into the alleles Gc1F and Gc1S. The distribution of Gc1 subtypes was very different in three populations (Pygmies, Amerindians, and Pyreneans) examined. New variants of the Gc1 and Gc2 genes were also described in the Amerindians and in the Pygmy population, respectively.

Citing Articles

Group-specific component (Gc) subtypes in the Chinese population of Hong Kong.

Kwok K, Lewis W Hum Genet. 1981; 59(1):72-4.

PMID: 10819026 DOI: 10.1007/BF00278858.

Human transferrin (Tf) and group-specific component (Gc) subtypes in Tunisia.

Lefranc M, Chibani J, Helal A, Boukef K, Seger J, Lefranc G Hum Genet. 1981; 59(1):60-3.

PMID: 10819023 DOI: 10.1007/BF00278855.

Genetic markers associated with high versus low performance on episodic memory tasks.

Nilsson L, Sikstrom C, Adolfsson R, Erngrund K, Nylander P, Beckman L Behav Genet. 1996; 26(6):555-62.

PMID: 8990534 DOI: 10.1007/BF02361228.

Hereditary recombined three-allele variant of the Gc system.

Kubo S, KITAMURA O, Tsuda R, Hirose W, Matsumoto H, Nakasono I Hum Genet. 1993; 91(1):71-2.

PMID: 8454291 DOI: 10.1007/BF00230226.

Distribution of Gc-subtypes in Western Germany (Düsseldorf region).

Scheil H, Driesel A, ROHRBORN G Z Rechtsmed. 1980; 84(2):95-7.

PMID: 7376746 DOI: 10.1007/BF02114578.

References

KITCHIN F, Bearn A . QUANTITATIVE DETERMINATION OF THE GROUP SPECIFIC PROTEIN IN NORMAL HUMAN SERUM. Proc Soc Exp Biol Med. 1965; 118:304-7. DOI: 10.3181/00379727-118-29827. View

Hirschfeld J . The Gc-system. Immuno-electrophoretic studies of normal human sera with special reference to a new genetically determined system (Gc). Prog Allergy. 1962; 6:155-86. View

Alper C, Johnson A . Immunofixation electrophoresis: a technique for the study of protein polymorphism. Vox Sang. 1969; 17(5):445-52. DOI: 10.1111/j.1423-0410.1969.tb00414.x. View

Ritchie R, Smith R . Immunofixation. I. General principles and application to agarose gel electrophoresis. Clin Chem. 1976; 22(4):497-9. View

CLEVE H, Kirk R, Parker W, Bearn A, Schacht L, Kleinman H . TWO GENETIC VARIANTS OF THE GROUP-SPECIFIC COMPONENT OF HUMAN SERUM: GC CHIPPEWA AND GC ABORIGINE. Am J Hum Genet. 1963; 15:368-79. PMC: 1932554. View

KITCHIN F, Bearn A . The electrophoretic patterns of normal and variant phenotypes of the group specific (Gc) components in human serum. Am J Hum Genet. 1966; 18(2):201-14. PMC: 1706170. View

CLEVE H, KITCHIN F, KIRCHBERG G, WENDT G . A faster migrating Gc-variant: Gc Darmstadt. Humangenetik. 1970; 9(1):26-33. DOI: 10.1007/BF00696010. View

RUCKNAGEL D, Shreffler D, Halstead S . The Bangkok variant of the serum group-specific component (Gc) and the frequency of the Gc alleles in Thailand. Am J Hum Genet. 1968; 20(5):478-85. PMC: 1706346. View

Johnson A, CLEVE H, Alper C . Variants of the group-specific component system as demonstrated by immunofixation electrophoresis. Report of a new variant, Gc Boston (Ge B). Am J Hum Genet. 1975; 27(6):728-36. PMC: 1762900. View

10.

Vavrusa B, CLEVE H . Gc Opava: a variant of the group-specific component (Gc) system with an electrophoretic mobility intermediate between Gc 1-1 and Gc 2-2. Vox Sang. 1974; 26(2):157-62. DOI: 10.1111/j.1423-0410.1974.tb02681.x. View

11.

SPEISER P, PAUSCH V, CLEVE H . A new rapid migrating variant in the Gc-system: Gc Wien. Humangenetik. 1972; 17(1):81-4. DOI: 10.1007/BF01789606. View

12.

Parker W, CLEVE H, Bearn A . DETERMINATION OF PHENOTYPES IN THE HUMAN GROUP-SPECIFIC COMPONENT (GC) SYSTEM BY STARCH GEL ELECTROPHORESIS. Am J Hum Genet. 1963; 15:353-67. PMC: 1932560. View

13.

REINSKOU T . A new variant in the Gc system. Acta Genet Stat Med. 1965; 15(3):248-55. DOI: 10.1159/000151917. View

14.

Hirschfeld J . Immune-electrophoretic demonstration of qualitative differences in human sera and their relation to the haptoglobins. Acta Pathol Microbiol Scand. 1959; 47:160-8. DOI: 10.1111/j.1699-0463.1959.tb04844.x. View

15.

Omoto K, CLEVE H, Misawa S . A new variant phenotype of the group-specific component (Gc) found in a Japanese family. Jinrui Idengaku Zasshi. 1972; 17(1):1-9. View

16.

Hennig W, Hoppe H . A NEW ALLELE IN THE GC-SYSTEM: GC. Vox Sang. 1965; 10:214-7. DOI: 10.1111/j.1423-0410.1965.tb04341.x. View

17.

Persson I, TINGSGAARD P . A DEVIATING GC TYPE. Acta Genet Stat Med. 1965; 15:51-6. DOI: 10.1159/000151890. View

18.

Constans J, CLEVE H, Viau M, Gouaillard C . GcT (Toulouse): a fast variant of the groupspecific system in an Pyrenean family. Vox Sang. 1978; 34(1):46-50. DOI: 10.1111/j.1423-0410.1978.tb02880.x. View

19.

Daiger S, Schanfield M, Cavalli-Sforza L . Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Proc Natl Acad Sci U S A. 1975; 72(6):2076-80. PMC: 432697. DOI: 10.1073/pnas.72.6.2076. View