First Line Targeted Radiotherapy, a New Concept in the Treatment of Advanced Stage Neuroblastoma

Overview

Journal Eur J Cancer

Specialty Oncology

Date 1995 Jan 1

PMID 7576977

Citations 14

Authors

J de Kraker

C A Hoefnagel

H Caron

R A Valdes Olmos

J Zsiros

H A Heij

P A VOUTE

Affiliations

Soon will be listed here.

Abstract

33 previously untreated advanced stage neuroblastoma patients were treated with [131I]meta-iodobenzylguanidine (MIBG). The number of treatments varied between 2 and 7 per patient (mean 3). Toxicity was seldom severe. Only thrombocytopenia WHO-grade 4 was noticed. Response was documented before surgery for the primary tumour was performed. There was one complete response (CR), 18 partial responses (PR), 11 had stable disease (SD) and 3 had progressive disease (PD). After MIBG therapy and surgery, 12 of 33 patients achieved a CR. This approach is feasible, comparable to multidrug chemotherapy in efficacy and less toxic. Long term results are not known yet.

Citing Articles

The efficacy and safety of Iodine-131-metaiodobenzylguanidine therapy in patients with neuroblastoma: a meta-analysis.

He H, Xu Q, Yu C BMC Cancer. 2022; 22(1):216.

PMID: 35227236 PMC: 8883646. DOI: 10.1186/s12885-022-09329-2.

A safety and feasibility trial of I-MIBG in newly diagnosed high-risk neuroblastoma: A Children's Oncology Group study.

Weiss B, Yanik G, Naranjo A, Zhang F, Fitzgerald W, Shulkin B Pediatr Blood Cancer. 2021; 68(10):e29117.

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Upfront consolidation treatment with I-mIbG followed by myeloablative chemotherapy and hematopoietic stem cell transplantation in high-risk neuroblastoma.

Feng J, Cheng F, Leung A, Lee V, Yeung E, Ching Lam H Pediatr Investig. 2020; 4(3):168-177.

PMID: 33150310 PMC: 7520103. DOI: 10.1002/ped4.12216.

Iodine-131-meta-iodobenzylguanidine therapy for patients with newly diagnosed high-risk neuroblastoma.

Kraal K, van Dalen E, Tytgat G, Van Eck-Smit B Cochrane Database Syst Rev. 2017; 4:CD010349.

PMID: 28429876 PMC: 6478145. DOI: 10.1002/14651858.CD010349.pub2.

Nothing but NET: a review of norepinephrine transporter expression and efficacy of 131I-mIBG therapy.

Streby K, Shah N, Ranalli M, Kunkler A, Cripe T Pediatr Blood Cancer. 2014; 62(1):5-11.

PMID: 25175627 PMC: 4237663. DOI: 10.1002/pbc.25200.