Expression of Lactococcin A and Pediocin PA-1 in Heterologous Hosts

Overview

Journal Lett Appl Microbiol

Publisher Oxford University Press

Specialty Microbiology

Date 1995 Sep 1

PMID 7576505

Citations 15

Authors

M L Chikindas

K Venema

A M Ledeboer

G Venema

J Kok

Affiliations

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Abstract

Pediocin PA-1 production, immunity and secretion are specified by a cluster of four genes in Pediococcus acidilactici PAC1.0. The production by, secretion of, and immunity to lactococcin A of Lactococcus lactis are also determined by four genes. Here, expression of the pediocin operon in Lactococcus lactis is reported, which could only be achieved by placing it under control of a lactococcal promoter. Expression of the lactococcin A operon in Pediococcus is also described: recombinant clones of Pediococcus were obtained that produced and secreted both active pediocin PA-1 and lactococcin A.

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Ocins for Food Safety.

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