Cytokine Network in the Central Nervous System and Its Roles in Growth and Differentiation of Glial and Neuronal Cells

Overview

Journal Int J Dev Neurosci

Specialty Neurology

Date 1995 Jun 1

PMID 7572279

Citations 32

Authors

M Sawada

A Suzumura

T Marunouchi

Affiliations

Soon will be listed here.

Abstract

Cells resident within the central nervous system (CNS) can synthesize, secrete and respond to inflammatory cytokines not only contributing to the responses to injury or immunological challenge within the CNS, but also regulating their own growth and differentiation potential. The actions and cell communication via cytokines in the CNS are designated as the CNS cytokine network, in which microglia and astrocytes play the central roles. To further characterize the CNS cytokine network we investigated the differences in roles of these cells, and found that microglia might contribute to the early phase of cytokine production reaction and that astrocytes might contribute the late phase of the reaction. We also investigated roles of inhibitory cytokines such as TGF beta, IL-4, and IL-10, and showed that each might play a distinct role in the inhibitory regulation in the CNS. We summarized our previous report about cellular distribution of cytokine receptors in the CNS cells and discussed their roles in the CNS cytokine network. Finally, we investigated that expression of IL-6 and IL-2 receptors in neuronal and oligodendrocytic differentiation, respectively. From these results, we discussed the features of the CNS cytokine network.

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References

TANABE O, Akira S, Kamiya T, Wong G, Hirano T, Kishimoto T . Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human. J Immunol. 1988; 141(11):3875-81. View

Ohno K, Suzumura A, Sawada M, Marunouchi T . Production of granulocyte/macrophage colony-stimulating factor by cultured astrocytes. Biochem Biophys Res Commun. 1990; 169(2):719-24. DOI: 10.1016/0006-291x(90)90390-9. View

Hart P, Vitti G, Burgess D, Whitty G, Piccoli D, Hamilton J . Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2. Proc Natl Acad Sci U S A. 1989; 86(10):3803-7. PMC: 287229. DOI: 10.1073/pnas.86.10.3803. View

Howard M, OGarra A, Ishida H, de Waal Malefyt R, de Vries J . Biological properties of interleukin 10. J Clin Immunol. 1992; 12(4):239-47. DOI: 10.1007/BF00918147. View

Suzumura A, Mezitis S, Gonatas N, Silberberg D . MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by gamma-interferon. J Neuroimmunol. 1987; 15(3):263-78. PMC: 7133952. DOI: 10.1016/0165-5728(87)90121-4. View

Lowenthal J, Castle B, Christiansen J, Schreurs J, Rennick D, Arai N . Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells. J Immunol. 1988; 140(2):456-64. View

Morganti-Kossmann M, Kossmann T, Wahl S . Cytokines and neuropathology. Trends Pharmacol Sci. 1992; 13(7):286-91. DOI: 10.1016/0165-6147(92)90087-m. View

Tsunawaki S, Sporn M, Ding A, Nathan C . Deactivation of macrophages by transforming growth factor-beta. Nature. 1988; 334(6179):260-2. DOI: 10.1038/334260a0. View

Sawada M, Suzumura A, Itoh Y, Marunouchi T . Production of interleukin-5 by mouse astrocytes and microglia in culture. Neurosci Lett. 1993; 155(2):175-8. DOI: 10.1016/0304-3940(93)90701-l. View

10.

Giulian D, Baker T, Shih L, Lachman L . Interleukin 1 of the central nervous system is produced by ameboid microglia. J Exp Med. 1986; 164(2):594-604. PMC: 2188228. DOI: 10.1084/jem.164.2.594. View

11.

Zhang Y, Lin J, Yip Y, Vilcek J . Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6. Proc Natl Acad Sci U S A. 1988; 85(18):6802-5. PMC: 282066. DOI: 10.1073/pnas.85.18.6802. View

12.

Benveniste E, Merrill J . Stimulation of oligodendroglial proliferation and maturation by interleukin-2. Nature. 1986; 321(6070):610-3. DOI: 10.1038/321610a0. View

13.

Suzumura A, Lavi E, Weiss S, Silberberg D . Coronavirus infection induces H-2 antigen expression on oligodendrocytes and astrocytes. Science. 1986; 232(4753):991-3. DOI: 10.1126/science.3010460. View

14.

Sawada M, Kondo N, Suzumura A, Marunouchi T . Production of tumor necrosis factor-alpha by microglia and astrocytes in culture. Brain Res. 1989; 491(2):394-7. DOI: 10.1016/0006-8993(89)90078-4. View

15.

Hopkins S, Humphreys M . Simple, sensitive and specific bioassay of interleukin-1. J Immunol Methods. 1989; 120(2):271-6. DOI: 10.1016/0022-1759(89)90252-4. View

16.

Sawada M, Suzumura A, Marunouchi T . Down regulation of CD4 expression in cultured microglia by immunosuppressants and lipopolysaccharide. Biochem Biophys Res Commun. 1992; 189(2):869-76. DOI: 10.1016/0006-291x(92)92284-5. View

17.

Essner R, Rhoades K, McBride W, Morton D, Economou J . IL-4 down-regulates IL-1 and TNF gene expression in human monocytes. J Immunol. 1989; 142(11):3857-61. View

18.

Bazin R, Lemieux R . Role of the macrophage-derived hybridoma growth factor in the in vitro and in vivo proliferation of newly formed B cell hybridomas. J Immunol. 1987; 139(3):780-7. View

19.

Sawada M, Suzumura A, Kondo N, Marunouchi T . Induction of cytokines in glial cells by trans activator of human T-cell lymphotropic virus type I. FEBS Lett. 1992; 313(1):47-50. DOI: 10.1016/0014-5793(92)81181-k. View

20.

Suzumura A, Marunouchi T, Yamamoto H . Morphological transformation of microglia in vitro. Brain Res. 1991; 545(1-2):301-6. DOI: 10.1016/0006-8993(91)91302-h. View