Iodine Content of Human Tissues After Administration of Iodine Containing Drugs or Contrast Media

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 1978 Jul 1

PMID 756875

Citations 5

Authors

A Costa

O B Testori

C Cenderelli

G Giribone

M Migliardi

Affiliations

Soon will be listed here.

Abstract

Total iodine contents were determined in 209 bioptic or autoptic specimens of various extrathyroidal tissues. Fifty-two of the 80 subjects examined had no previous exposure to excessive iodine, 24 were tested after administration of x-ray contrast media and 4 after treatment with various iodine containing drugs. Unexposed subjects had tissue iodine contents (mean +/- SD) ranging from 0.85 +/- 0.17 microgram/100 g in the brain and 9.78 +/- 2.75 microgram/100 g in the liver of adults. A significantly lower iodine concentration was found in the liver of newborns (2.79 +/- 1.00 microgram, p less than 0.001). Most of the other tissues had iodine concentrations of 2-4 microgram/100 g. Subjects with previous exposure to iodine containing drugs or x-ray contrast media showed increased iodine contents of various degree in all examined tissues, including adipose tissue, bone, brain, kidney, liver, lung, skeletal muscle, skin and spleen. Accumulation of iodine in adipose tissue was still demonstrable more than two years after cholecystography.

Citing Articles

Preoperative Use of Intravenous Contrast Media Is Associated With Decreased Excellent Response Rates in Intermediate-Risk DTC Patients Who Subsequently Receive Total Thyroidectomy and Low-Dose RAI Therapy.

Lan W, Renjie W, Qichang W, Feiyue T, Qingjie M, Bin J Front Oncol. 2020; 10:1297.

PMID: 33042786 PMC: 7522438. DOI: 10.3389/fonc.2020.01297.

The Diagnostic Role of Computed Tomography for ACR TI-RADS 4-5 Thyroid Nodules With Coarse Calcifications.

Wei P, Jiang N, Ding J, Xiang J, Wang L, Wang H Front Oncol. 2020; 10:911.

PMID: 32582556 PMC: 7289989. DOI: 10.3389/fonc.2020.00911.

CT-detected solitary thyroid calcification: an important imaging feature for papillary carcinoma.

Yang T, Huang Y, Jing X, Gai X, Li W Onco Targets Ther. 2016; 9:6273-6279.

PMID: 27785075 PMC: 5067013. DOI: 10.2147/OTT.S113369.

Clinical features and treatment outcomes of 41 dogs with sublingual ectopic thyroid neoplasia.

Broome M, Peterson M, Walker J J Vet Intern Med. 2014; 28(5):1560-8.

PMID: 25056508 PMC: 4895559. DOI: 10.1111/jvim.12406.

The use of X-ray contrast media in the treatment of hyperthyroidism.

Costa A J Endocrinol Invest. 1979; 2(4):461-2.

PMID: 583424 DOI: 10.1007/BF03349350.

References

Thilly C, Delange F, ERMANS A . Endemic goiter prevention by iodized oil: a reassessment. J Clin Endocrinol Metab. 1973; 36(6):1196-204. DOI: 10.1210/jcem-36-6-1196. View

MALVANO R, Buzzigoli G, Scarlattini M, Cenderelli G, Gandolfi C, Grosso P . The determination of iodine in materials of biological interest. A comparative evaluation of neutron-activation and automated colorimetric method. Anal Chim Acta. 1972; 61(2):201-22. DOI: 10.1016/s0003-2670(01)95052-4. View

ODDIE T, Meade Jr J, Fisher D . An analysis of published data on thyroxine turnover in human subjects. J Clin Endocrinol Metab. 1966; 26(4):425-36. DOI: 10.1210/jcem-26-4-425. View

Wolff J, Thompson R, Robbins J . CONGENITAL GOITROUS CRETINISM DUE TO THE ABSENCE OF IODIDE-CONCENTRATING ABILITY. J Clin Endocrinol Metab. 1964; 24:699-707. DOI: 10.1210/jcem-24-8-699. View

Cottino F, Zoppetti G, Favero A, Lombardi M, Cenderelli G, Costa A . Placental tissue and maternal and cord serum iodine following pharmacological loading. Folia Endocrinol. 1972; 25(4):278-85. View

RIGGS D . Quantitative aspects of iodine metabolism in man. Pharmacol Rev. 1952; 4(3):284-370. View

MEDEIROS-NETO G, NICOLAU W . Effect of iodized oil on iodine content, thyroglobulin maturation and on biochemical constituents of endemic goitre in brazil. Acta Endocrinol (Copenh). 1975; 79(3):439-50. DOI: 10.1530/acta.0.0790439. View

KLITGAARD H, DIRKS Jr H, GARLICK W, BARKER S . Protein-bound iodine in various tissues after injection of elemental iodine. Endocrinology. 1952; 50(2):170-3. DOI: 10.1210/endo-50-2-170. View

Platzer S, Fill H, Riccabona G, GLATZL J, Seidl J, Cenderelli G . Endemic goitre in Alto Adige (Italy). Acta Endocrinol (Copenh). 1977; 85(2):325-34. DOI: 10.1530/acta.0.0850325. View

10.

MALVANO R, Buzzigoli G, Costa A, Cottino F . Iodine determination in human and mouse tissues by neutron-activation analysis. J Nucl Biol Med. 1969; 13(1):71-9. View

11.

Platzer S, Riccabona G, Fill H, Ladurner D, GLATZL J, De Sanso G . Notes on endemic goitre and cretinism in the upper Isarco valley. J Nucl Biol Med. 1975; 19(2):65-72. View

12.

Sonksen P, Ekins R, STEVENS H, Williams E, Nabarro J . Serum-levels of protein-bound iodine and thyroxine after a course of clioquinol. Lancet. 1968; 2(7565):425-6. DOI: 10.1016/s0140-6736(68)90466-2. View

13.

CARR Jr E, RIGGS D . Protein-bound iodine in extrathyroidal tissues. Biochem J. 1953; 54(2):217-25. PMC: 1268928. DOI: 10.1042/bj0540217. View

14.

Costa A, Bacci R, Cottino F, LISTORTO G, Zoppetti G . [Studies of iodine metabolism after total and subtotal strumectomy]. Minerva Med. 1970; 61(102):5918-22. View

15.

ALPERS J, RALL J . The metabolism of iodine in cerebrospinal fluid. J Clin Endocrinol Metab. 1955; 15(12):1482-98. DOI: 10.1210/jcem-15-12-1482. View