TRPC1, a Human Homolog of a Drosophila Store-operated Channel

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1995 Oct 10

PMID 7568191

Citations 218

Authors

P D Wes

J Chevesich

A Jeromin

C Rosenberg

G Stetten

C Montell

Affiliations

Soon will be listed here.

Abstract

In many vertebrate and invertebrate cells, inositol 1,4,5-trisphospate production induces a biphasic Ca2+ signal. Mobilization of Ca2+ from internal stores drives the initial burst. The second phase, referred to as store-operated Ca2+ entry (formerly capacitative Ca2+ entry), occurs when depletion of intracellular Ca2+ pools activates a non-voltage-sensitive plasma membrane Ca2+ conductance. Despite the prevalence of store-operated Ca2+ entry, no vertebrate channel responsible for store-operated Ca2+ entry has been reported. trp (transient receptor potential), a Drosophila gene required in phototransduction, encodes the only known candidate for such a channel throughout phylogeny. In this report, we describe the molecular characterization of a human homolog of trp, TRPC1. TRPC1 (transient receptor potential channel-related protein 1) was 40% identical to Drosophila TRP over most of the protein and lacked the charged residues in the S4 transmembrane region proposed to be required for the voltage sensor in many voltage-gated ion channels. TRPC1 was expressed at the highest levels in the fetal brain and in the adult heart, brain, testis, and ovaries. Evidence is also presented that TRPC1 represents the archetype of a family of related human proteins.

Citing Articles

Magnetically Stimulated Myogenesis Recruits a CRY2-TRPC1 Photosensitive Signaling Axis.

Iversen J, Tai Y, Wu K, Wong C, Lim H, Franco-Obregon A Cells. 2025; 14(3).

PMID: 39937022 PMC: 11817702. DOI: 10.3390/cells14030231.

Effects of TRPC1's Lysines on Heteromeric TRPC5-TRPC1 Channel Function.

Demaree I, Kumar S, Tennessen K, Hoang Q, White F, Obukhov A Cells. 2024; 13(23).

PMID: 39682767 PMC: 11640535. DOI: 10.3390/cells13232019.

Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel.

Won J, Kim J, Kim J, Ko J, Park C, Jeong B Nat Struct Mol Biol. 2024; 32(2):326-338.

PMID: 39478185 DOI: 10.1038/s41594-024-01408-1.

TRPC6 is ubiquitously present in lymphatic tissues: A study using samples from body donors.

Daum F, Flockerzi F, Bozzato A, Schick B, Tschernig T Med Int (Lond). 2024; 4(6):62.

PMID: 39161881 PMC: 11332316. DOI: 10.3892/mi.2024.186.

The odyssey of the TR(i)P journey to the cellular membrane.

Rivera B, Orellana-Serradell O, Servili E, Santos R, Brauchi S, Cerda O Front Cell Dev Biol. 2024; 12:1414935.

PMID: 39108834 PMC: 11300232. DOI: 10.3389/fcell.2024.1414935.

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