Erythrocyte Sodium-potassium Transport in Hyperkalaemic and Normokalaemic Infants

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 1995 Jul 1

PMID 7556326

Citations 1

Authors

Y Matsuo

K Hasegawa

Y Doi

A Kinugasa

M Uchiyama

T Sawada

Affiliations

Soon will be listed here.

Abstract

Unlabelled: One of the causes of early onset hyperkalaemia in very low birth weight infants is presumed to be the dysfunction of K+ transport across the cell membrane. Sodium-potassium adenosine triphosphatase(Na(+)-K+ ATPase) is known to play a major role in K+ transport. We compared the concentrations of erythrocyte Na(+)-K+ ATPase (Vmax levels) for hyperkalaemic and normokalaemic infants of matched gestational age. In hyperkalaemic infants, the highest levels of Vmax were reached at 24-48 h after birth, but in normokalaemic infants, there were no significant changes in Vmax levels during the 1st week after birth. At 12-72 h after birth, erythrocyte K+ concentrations for hyperkalaemic infants were higher than those of normokalaemic infants. For both groups of infants, the highest levels of plasma K+ during the 1st week after birth showed a positive correlation with those of Vmax.

Conclusion: Na(+)-K+ ATPase on the cell membrane is activated to compensate for hyperkalaemia; however, when this compensation is incomplete, hyperkalaemia occurs.

Citing Articles

Developmental changes in erythrocyte Na(+),K(+)-ATPase subunit abundance and enzyme activity in neonates.

Vasarhelyi B, Tulassay T, Ver A, Dobos M, Kocsis I, Seri I Arch Dis Child Fetal Neonatal Ed. 2000; 83(2):F135-8.

PMID: 10952709 PMC: 1721133. DOI: 10.1136/fn.83.2.f135.

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