The Interference by Maternally-derived Antibody with Active Immunization of Farm Animals Against Foot-and-mouth Disease

Overview

Journal Br Vet J

Specialty Veterinary Medicine

Date 1995 Jul 1

PMID 7552194

Citations 13

Authors

R P Kitching

J S Salt

Affiliations

Soon will be listed here.

Abstract

Foot-and-mouth disease (FMD) is a highly contagious disease affecting ruminants and pigs. In countries in which control of FMD relies predominantly on vaccination, young stock ingest specific anti-FMD virus antibodies in the colostrum. This maternally-derived antibody (MDA) provides immediate protection against infection with FMD virus, but also interferes with the development of active immunity following vaccination. However, susceptibility to infection precedes the ability to respond to vaccination in the presence of MDA. Currently available vaccines cannot overcome this inhibitory effect of MDA, and protection of young stock can only be provided by their isolation from FMD virus.

Citing Articles

Maternally Derived Antibodies to Foot-and-Mouth Disease Virus Modulate the Antigenic Specificity of Humoral Responses in Vaccinated Cattle.

Senawi J, Wilsden G, Browning C, Ludi A, Ismail M, Senin H Vaccines (Basel). 2023; 11(12).

PMID: 38140247 PMC: 10747493. DOI: 10.3390/vaccines11121844.

Does Vaccine-Induced Maternally-Derived Immunity Protect Swine Offspring against Influenza a Viruses? A Systematic Review and Meta-Analysis of Challenge Trials from 1990 to May 2021.

Keay S, Poljak Z, Alberts F, OConnor A, Friendship R, OSullivan T Animals (Basel). 2023; 13(19).

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Evaluation of the effectiveness of foot-and-mouth disease vaccination of animals in the buffer zone of the Republic of Armenia in 2016-2020.

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The C3d-fused foot-and-mouth disease vaccine platform overcomes maternally-derived antibody interference by inducing a potent adaptive immunity.

Lee M, Kim H, Shin S, Jo H, Park S, Kim S NPJ Vaccines. 2022; 7(1):70.

PMID: 35764653 PMC: 9240001. DOI: 10.1038/s41541-022-00496-8.

Age-Dependent Dynamics of Maternally Derived Antibodies (MDAs) and Understanding MDA-Mediated Immune Tolerance in Foot-and-Mouth Disease-Vaccinated Pigs.

Shin S, Park S, Park J, Kim S, Lee M Vaccines (Basel). 2022; 10(5).

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