The Subthalamo-nigral Pathway Regulates Movement and Concomitant Acetylcholinesterase Release from the Substantia Nigra

Overview

Journal J Neural Transm Gen Sect

Specialties Neurology
Physiology

Date 1994 Jan 1

PMID 7536013

Citations 1

Authors

S A Jones

B G Dickie

A Klegeris

S A Greenfield

Affiliations

Soon will be listed here.

Abstract

Within the substantia nigra acetylcholinesterase is released independently of cholinergic transmission: this release could be related to some aspects of motor control. To investigate this possibility, acetylcholinesterase release was continuously monitored in relation to specific movements evoked by central electrical stimulation. Increased intensities of stimulation of the subthalamic nucleus in awake guinea-pigs produced a behavioural response, ranging from a decrease in spontaneous movement, to chewing, to both chewing and circling movements. Enhancement of acetylcholinesterase release occurred only when large scale movements (circling as well as chewing) were evoked by subthalamic stimulation: however, a similar protocol of stimulation during ketamine-induced anaesthesia did not produce any comparable movements nor any concomitant change in the release of acetylcholinesterase. Perfusion of the glutamate agonist N-methyl-D-aspartate (NMDA) into the substantia nigra also induced an increase in release of acetylcholinesterase from the substantia nigra of conscious animals, whereas (S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) did not significantly enhance acetylcholinesterase levels. It is concluded that AChE release in the substantia nigra can occur as a result of activation of glutamatergic subthalamic afferents, and that this activation may also be associated with changes in movement.

Citing Articles

Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain.

Olivera S, Rodriguez-Ithurralde D, Henley J Br J Pharmacol. 2001; 133(7):1055-62.

PMID: 11487516 PMC: 1572873. DOI: 10.1038/sj.bjp.0704167.

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