Identification of Glioma-associated Antigen MUC 2-63 As CD44

Overview

Journal Br J Cancer

Specialty Oncology

Date 1994 Nov 1

PMID 7524600

Citations 2

Authors

P Romeijn

R Lenthall

D Stavrou

D Melcher

H Ladyman

M A Ritter

Affiliations

Soon will be listed here.

Abstract

Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies using MUC 2-63 and the CD44 anti-framework antibody F10-44-2. Thus not only MUC 2-63 but also other anti-CD44 monoclonal antibodies should prove useful in imaging and, perhaps, therapy of brain tumours.

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