Bruton Tyrosine Kinase is Tyrosine Phosphorylated and Activated in Pre-B Lymphocytes and Receptor-ligated B Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1994 Oct 25

PMID 7524098

Citations 59

Authors

Y Aoki

K J Isselbacher

S Pillai

Affiliations

Soon will be listed here.

Abstract

The gene encoding Bruton tyrosine kinase (Btk) is known to be mutated in human X chromosome-linked agammaglobulinemia and in the Xid mouse. This kinase was examined in B lymphocytes before and after antigen receptor ligation and also in pre-B cells. Btk was found to be catalytically activated and tyrosine phosphorylated in response to anti-IgM stimulation in B cells. This kinase is also constitutively phosphorylated on tyrosine residues in pre-B cells. These findings point to a functional role for Btk in pre-antigen and antigen receptor signaling during B-cell development and provide a biochemical explanation for the X-linked genetic syndromes already linked to this kinase.

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