Progressive Increase of CD7- T Cells in Human Blood Lymphocytes with Ageing

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1994 Oct 1

PMID 7523007

Citations 10

Authors

S Kukel

U Reinhold

I Oltermann

H W Kreysel

Affiliations

Soon will be listed here.

Abstract

CD7 is one of the major surface antigens expressed very early during T cell ontogeny. Lack of CD7 expression on mature T cells is regarded as a classical feature of malignant T cells in certain forms of cutaneous T cell lymphoma. Previously, we identified a CD7- subset of peripheral blood T lymphocytes in normal human individuals. In this study we determined the portion of CD7- T cells in the peripheral blood of healthy volunteers ranging in age from 8 months to 90 years (n = 85) and in cord blood of full-term infants (n = 14). Furthermore, this CD7- subset was characterized in detail by the use of MoAbs and three-colour flow cytometry. In cord blood no CD7- T cells could be detected. After birth, percentage and absolute number of CD7- T cells increased with age. Independently of age, most CD7-CD3+ cells belonged to the CD4+ subpopulation. Focusing on the latter we could demonstrate the predominance of the CD45RO+CD45RA- phenotype in the CD7- subset. Furthermore, CD7- T cells contained a higher number of cells expressing activation markers and the CD57 antigen, but a reduced number of CD62L+ cells in comparison with CD7+ T cells.

Citing Articles

Chimeric antigen receptor T-cell therapy for T-cell acute lymphoblastic leukemia.

Oh B, Vinanica N, Wong D, Campana D Haematologica. 2024; 109(6):1677-1688.

PMID: 38832423 PMC: 11141683. DOI: 10.3324/haematol.2023.283848.

CD158k and PD-1 expressions define heterogeneous subtypes of Sezary syndrome.

Vergnolle I, Douat-Beyries C, Boulinguez S, Rieu J, Vial J, Baracou R Blood Adv. 2021; 6(6):1813-1825.

PMID: 34570200 PMC: 8941477. DOI: 10.1182/bloodadvances.2021005147.

HIV Impacts CD34 Progenitors Involved in T-Cell Differentiation During Coculture With Mouse Stromal OP9-DL1 Cells.

Tsukamoto T Front Immunol. 2019; 10:81.

PMID: 30761146 PMC: 6361802. DOI: 10.3389/fimmu.2019.00081.

Clinical end points and response criteria in mycosis fungoides and Sézary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of....

Olsen E, Whittaker S, Kim Y, Duvic M, Prince H, Lessin S J Clin Oncol. 2011; 29(18):2598-607.

PMID: 21576639 PMC: 3422534. DOI: 10.1200/JCO.2010.32.0630.

The role of 9-O-acetylated ganglioside D3 (CD60) and {alpha}4{beta}1 (CD49d) expression in predicting the survival of patients with Sezary syndrome.

Scala E, Abeni D, Pomponi D, Narducci M, Lombardo G, Mari A Haematologica. 2010; 95(11):1905-12.

PMID: 20663947 PMC: 2966913. DOI: 10.3324/haematol.2010.026260.

References

Lobach D, Hensley L, Ho W, Haynes B . Human T cell antigen expression during the early stages of fetal thymic maturation. J Immunol. 1985; 135(3):1752-9. View

Link M, Warnke R, Finlay J, Amylon M, Miller R, Dilley J . A single monoclonal antibody identifies T-cell lineage of childhood lymphoid malignancies. Blood. 1983; 62(4):722-8. View

Sanders M, Makgoba M, Sharrow S, Stephany D, Springer T, Young H . Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. J Immunol. 1988; 140(5):1401-7. View

Serra H, Krowka J, Ledbetter J, Pilarski L . Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event. J Immunol. 1988; 140(5):1435-41. View

Akbar A, Terry L, Timms A, Beverley P, Janossy G . Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol. 1988; 140(7):2171-8. View

Pitzalis C, Kingsley G, Haskard D, Panayi G . The preferential accumulation of helper-inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion. Eur J Immunol. 1988; 18(9):1397-404. DOI: 10.1002/eji.1830180915. View

Carrera A, Rincon M, Sanchez-Madrid F, Lopez-Botet M, de Landazuri M . Triggering of co-mitogenic signals in T cell proliferation by anti-LFA-1 (CD18, CD11a), LFA-3, and CD7 monoclonal antibodies. J Immunol. 1988; 141(6):1919-24. View

MERKENSCHLAGER M, Terry L, Edwards R, Beverley P . Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation. Eur J Immunol. 1988; 18(11):1653-61. DOI: 10.1002/eji.1830181102. View

Yamashita N, Clement L . Phenotypic characterization of the post-thymic differentiation of human alloantigen-specific CD8+ cytotoxic T lymphocytes. J Immunol. 1989; 143(5):1518-23. View

10.

Sanders M, Makgoba M, Shaw S . Human naive and memory T cells: reinterpretation of helper-inducer and suppressor-inducer subsets. Immunol Today. 1988; 9(7-8):195-9. DOI: 10.1016/0167-5699(88)91212-1. View

11.

Ware R, Scearce R, Dietz M, Starmer C, Palker T, Haynes B . Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. J Immunol. 1989; 143(11):3632-40. View

12.

Jackson A, Matsumoto H, Janszen M, Maino V, Blidy A, Shye S . Restricted expression of p55 interleukin 2 receptor (CD25) on normal T cells. Clin Immunol Immunopathol. 1990; 54(1):126-33. DOI: 10.1016/0090-1229(90)90012-f. View

13.

Damle N, Doyle L . Ability of human T lymphocytes to adhere to vascular endothelial cells and to augment endothelial permeability to macromolecules is linked to their state of post-thymic maturation. J Immunol. 1990; 144(4):1233-40. View

14.

Wallace D, Beverley P . Phenotypic changes associated with activation of CD45RA+ and CD45RO+ T cells. Immunology. 1990; 69(3):460-7. PMC: 1385968. View

15.

Sterry W, Bruhn S, Kunne N, Lichtenberg B, Brasch J, Mielke V . Dominance of memory over naive T cells in contact dermatitis is due to differential tissue immigration. Br J Dermatol. 1990; 123(1):59-64. DOI: 10.1111/j.1365-2133.1990.tb01824.x. View

16.

Beverley P . Functional analysis of human T cell subsets defined by CD45 isoform expression. Semin Immunol. 1992; 4(1):35-41. View

17.

Bell E . Function of CD4 T cell subsets in vivo: expression of CD45R isoforms. Semin Immunol. 1992; 4(1):43-50. View

18.

Pietschmann P, Cush J, Lipsky P . Identification of subsets of human T cells capable of enhanced transendothelial migration. J Immunol. 1992; 149(4):1170-8. View

19.

Zola H, Flego L, Macardle P, Donohoe P, Ranford J, Roberton D . The CD45RO (p180, UCHL1) marker: complexity of expression in peripheral blood. Cell Immunol. 1992; 145(1):175-86. DOI: 10.1016/0008-8749(92)90321-f. View

20.

Reinhold U, Abken H, Kukel S, Moll M, Muller R, Oltermann I . CD7- T cells represent a subset of normal human blood lymphocytes. J Immunol. 1993; 150(5):2081-9. View