NK1 Receptors Mediate Tachykinin-induced Plasma Extravasation in the Rat Knee Joint

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1993 Nov 1

PMID 7517617

Citations 3

Authors

Y Hirayama

R Yasumitsu

A Kawamura

T Fujii

Affiliations

Soon will be listed here.

Abstract

The tachykinin receptor type that mediates tachykinin-induced plasma extravasation in the rat knee joint was identified by using selective antagonists as well as natural or synthetic agonists. Substance P (SP) and neurokinin (NK) A induced plasma extravasation with almost the same potency and the maximum response was obtained at 5 nmol/knee. NKB was about ten times less potent than SP or NKA. The NK1 selective agonist, [Sar9, Met(O2)11]-SP, was about ten times more potent than SP, and the NK2 selective agonist, [Nle10]-NKA4-10, was about fifty times less potent than NK1 agonist. The NK3 agonist, Senktide, was totally ineffective at 0.5-50 nmol/knee. All responses induced by SP (5 nmol/knee), NKA (5 nmol/knee), NKB (50 nmol/knee), NK1 agonist (0.5 nmol/knee) or NK2 agonist (25 nmol/knee) were significantly and profoundly inhibited by the NK1 selective antagonist, RP67580, but not by the NK2 selective antagonist, SR48968. Taken together, we conclude that tachykinin-induced plasma extravasation in the rat knee joint is mediated via NK1 receptors.

Citing Articles

Characterization of tachykinin receptors mediating plasma extravasation and vasodilatation in normal and acutely inflamed knee joints of the rat.

Lam F, Wong M Br J Pharmacol. 1996; 118(8):2107-14.

PMID: 8864549 PMC: 1909878. DOI: 10.1111/j.1476-5381.1996.tb15650.x.

Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear.

Inoue H, Nagata N, Koshihara Y Inflamm Res. 1996; 45(7):316-23.

PMID: 8841832 DOI: 10.1007/BF02252943.

Involvement of substance P as a mediator in capsaicin-induced mouse ear oedema.

Inoue H, Nagata N, Koshihara Y Inflamm Res. 1995; 44(11):470-4.

PMID: 8597880 DOI: 10.1007/BF01837912.

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