Decay-accelerating Factor (CD55), a Glycosylphosphatidylinositol-anchored Complement Regulatory Protein, is a Receptor for Several Echoviruses

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1994 Jun 21

PMID 7517044

Citations 126

Authors

J M Bergelson

M Chan

K R Solomon

N F St John

H Lin

R W Finberg

Affiliations

Soon will be listed here.

Abstract

Echoviruses are human pathogens belonging to the picornavirus family. Decay-accelerating factor (DAF) is a glycosylphosphatidylinositol (GPI)-anchored surface protein that protects cells from lysis by autologous complement. Anti-DAF monoclonal antibodies prevented echovirus 7 attachment to susceptible cells and protected cells from infection. HeLa cells specifically lost the capacity to bind echovirus 7 when treated with phosphatidylinositol-specific phospholipase C, an enzyme that releases GPI-anchored proteins from the cell surface, indicating that the virus receptor, like DAF, is a GPI-anchored protein. Although Chinese hamster ovary cells do not bind echovirus 7, transfectants expressing human DAF bound virus efficiently, and binding was prevented by pretreatment with an anti-DAF monoclonal antibody. Anti-DAF antibodies prevented infection by at least six echovirus serotypes. These results indicate that DAF is the receptor mediating attachment and infection by several echoviruses.

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