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Spinal Co-administration of Peptide Substance P Antagonist Increases Antinociceptive Effect of the Opioid Peptide Biphalin

Overview
Journal Life Sci
Publisher Elsevier
Date 1994 Jan 1
PMID 7511201
Citations 16
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Abstract

Intrathecal injection of 0.25 micrograms of undecapeptide substance P antagonist (SPA) produced transient antinociception with a peak effect at 5 min. Increasing the SPA dose resulted in neurotoxicity. Intrathecal injection of the opioid peptide biphalin (BIP) produced antinociception for over 3 hrs without neurotoxicity. Co-administration of SPA (at subtoxic doses) increased BIP's antinociceptive effect. Naltrexone reversed analgesia due to BIP alone as well as after BIP+SPA.

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