Biodevelopmental Aspects of Conduct Disorder in Boys

Overview

Journal Child Psychiatry Hum Dev

Specialties Pediatrics
Psychiatry

Date 1993 Jan 1

PMID 7507018

Authors

S Gabel

J Stadler

J Bjorn

R Shindledecker

C L Bowden

Affiliations

Soon will be listed here.

Abstract

The association between biochemical parameters and conduct disorder (CD) was studied in 22 boys admitted to a residential center. Three-methoxy-4-hydroxyphenylglycol (MHPG) levels were significantly higher in prepubertal CD youth than in pubertal/post pubertal CD youth. Homovanillic acid (HVA) levels were significantly lower in CD youth under age 12.0 years than in non CD youth under age 12.0 years. The implications of these biodevelopmental findings in the study of CD are discussed.

References

Pliszka S, Rogeness G, Medrano M . DBH, MHPG, and MAO in children with depressive, anxiety, and conduct disorders: relationship to diagnosis and symptom ratings. Psychiatry Res. 1988; 24(1):35-44. DOI: 10.1016/0165-1781(88)90137-0. View

Seifert Jr W, Foxx J, Butler I . Age effect on dopamine and serotonin metabolite levels in cerebrospinal fluid. Ann Neurol. 1980; 8(1):38-42. DOI: 10.1002/ana.410080106. View

Kruesi M, Rapoport J, HAMBURGER S, Hibbs E, Potter W, Lenane M . Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiatry. 1990; 47(5):419-26. DOI: 10.1001/archpsyc.1990.01810170019003. View

Cloninger C . A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry. 1987; 44(6):573-88. DOI: 10.1001/archpsyc.1987.01800180093014. View

Virkkunen M, de Jong J, Bartko J, Linnoila M . Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters. Arch Gen Psychiatry. 1989; 46(7):604-6. DOI: 10.1001/archpsyc.1989.01810070030004. View

Virkkunen M, de Jong J, Bartko J, Goodwin F, Linnoila M . Relationship of psychobiological variables to recidivism in violent offenders and impulsive fire setters. A follow-up study. Arch Gen Psychiatry. 1989; 46(7):600-3. DOI: 10.1001/archpsyc.1989.01810070026003. View

Riddle M, Leckman J, Anderson G, Ort S, Hardin M, Stevenson J . Plasma-free homovanillic acid: within- and across-day stability in children and adults with Tourette's syndrome. Life Sci. 1987; 40(22):2145-51. DOI: 10.1016/0024-3205(87)90004-x. View

Zoccolillo M . Co-occurrence of conduct disorder and its adult outcomes with depressive and anxiety disorders: a review. J Am Acad Child Adolesc Psychiatry. 1992; 31(3):547-56. DOI: 10.1097/00004583-199205000-00024. View

Major L, Lerner P, Goodwin F, Ballenger J, Brown G, Lovenberg W . Dopamine beta-hydroxylase in CSF. Relationship to personality measures. Arch Gen Psychiatry. 1980; 37(3):308-10. DOI: 10.1001/archpsyc.1980.01780160078009. View

10.

Raine A, Venables P, Williams M . Relationships between central and autonomic measures of arousal at age 15 years and criminality at age 24 years. Arch Gen Psychiatry. 1990; 47(11):1003-7. DOI: 10.1001/archpsyc.1990.01810230019003. View

11.

Rogeness G, Hernandez J, Macedo C, Mitchell E, Amrung S, Harris W . Clinical characteristics of emotionally disturbed boys with very low activities of dopamine-beta-hydroxylase. J Am Acad Child Psychiatry. 1984; 23(2):203-8. DOI: 10.1097/00004583-198403000-00013. View

12.

Rogeness G, Hernandez J, Macedo C, Mitchell E . Biochemical differences in children with conduct disorder socialized and undersocialized. Am J Psychiatry. 1982; 139(3):307-11. DOI: 10.1176/ajp.139.3.307. View

13.

Cohen D, Shaywitz B, Johnson W, BOWERS Jr M . Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid. Arch Gen Psychiatry. 1974; 31(6):845-53. DOI: 10.1001/archpsyc.1974.01760180085011. View

14.

Rogeness G, Javors M, Maas J, Macedo C . Catecholamines and diagnoses in children. J Am Acad Child Adolesc Psychiatry. 1990; 29(2):234-41. DOI: 10.1097/00004583-199003000-00012. View

15.

Rogeness G, Javors M, Maas J, Macedo C, Fischer C . Plasma dopamine-beta-hydroxylase, HVA, MHPG, and conduct disorder in emotionally disturbed boys. Biol Psychiatry. 1987; 22(9):1158-62. DOI: 10.1016/0006-3223(87)90058-8. View

16.

Cloninger C . Neurogenetic adaptive mechanisms in alcoholism. Science. 1987; 236(4800):410-6. DOI: 10.1126/science.2882604. View

17.

Brown G, Goodwin F, Ballenger J, Goyer P, Major L . Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res. 1979; 1(2):131-9. DOI: 10.1016/0165-1781(79)90053-2. View

18.

Riddle M, Leckman J, Anderson G, Ort S, Hardin M, Stevenson J . Plasma MHPG: within- and across-day stability in children and adults with Tourette's syndrome. Biol Psychiatry. 1988; 24(4):391-8. DOI: 10.1016/0006-3223(88)90175-8. View

19.

Yuwiler A, Plotkin S, Geller E, Ritvo E . A rapid accurate procedure for the determination of serotonin in whole human blood. Biochem Med. 1970; 3(5):426-31. DOI: 10.1016/0006-2944(70)90010-4. View

20.

Bowden C, Deutsch C, Swanson J . Plasma dopamine-beta-hydroxylase and platelet monoamine oxidase in attention deficit disorder and conduct disorder. J Am Acad Child Adolesc Psychiatry. 1988; 27(2):171-4. DOI: 10.1097/00004583-198803000-00006. View